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R-Pro-(decarboxy-Pro)-X99

General

Type : Pyrrolidine,Isoindole,Indole

Chemical_Nomenclature : 2-[3-[(2S)-4,4-difluoro-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-3-oxopropyl]isoindole-1,3-dione

Canonical SMILES : C1CCN(C1)C(=O)C2CC(CN2C(=O)CCN3C(=O)C4=CC=CC=C4C3=O)(F)F

InChI : InChI=1S\/C20H21F2N3O4\/c21-20(22)11-15(19(29)23-8-3-4-9-23)25(12-20)16(26)7-10-24-17(27)13-5-1-2-6-14(13)18(24)28\/h1-2,5-6,15H,3-4,7-12H2\/t15-\/m0\/s1

InChIKey : ZSXNPAWXICXNGZ-HNNXBMFYSA-N

Other name(s) : CHEMBL458975,3eq7,BDBM50274983,DB08739,2-{3-[(2S)-4,4-Difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl}isoindole-1,3(2H)-dione

MW : 405.40

Formula : C20H21F2N3O4

CAS_number :

PubChem : 25102845

UniChem : ZSXNPAWXICXNGZ-HNNXBMFYSA-N

IUPHAR :

Wikipedia :

Target

Families : R-Pro-(decarboxy-Pro)-X99 ligand of proteins in family: S9N_PPCE_Peptidase_S9

Stucture : 3EQ7 Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors 1

Protein : pig-ppce

References (1)

Title : Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules - Kanai_2008_J.Med.Chem_51_7514
Author(s) : Kannai K , Aranyi P , Bocskei Z , Ferenczy G , Harmat V , Simon K , Batori S , Naray-Szabo G , Hermecz I
Ref : Journal of Medicinal Chemistry , 51 :7514 , 2008
Abstract : Kanai_2008_J.Med.Chem_51_7514
ESTHER : Kanai_2008_J.Med.Chem_51_7514
PubMedSearch : Kanai_2008_J.Med.Chem_51_7514
PubMedID: 19006380
Gene_locus related to this paper: pig-q6q2c2