Rh-pNP
The incorporation of a synthetic, catalytically competent metallo cofactor into a protein scaffold to generate an artificial metalloenzyme (ArM) lead to new activities specific of the cofactor. The new enzymes show racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol
General
Type : Organophosphate,Pincer-Metal-cofactor,pNP
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InChI :
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MW : 815.20
Formula : C39H55ClN3O5PRh
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Target
Families : Rh-pNP ligand of proteins in family: Canar_LipB || Cutinase
Stucture :
Protein : canar-LipB || fusso-cutas
References (1)
| Title : Lipase active site covalent anchoring of Rh(NHC) catalysts: towards chemoselective artificial metalloenzymes - Basauri-Molina_2015_Chem.Commun.(Camb)_51_6792 |
| Author(s) : Basauri-Molina M , Riemersma CF , Wurdemann MA , Kleijn H , Klein Gebbink RJ |
| Ref : Chem Commun (Camb) , 51 :6792 , 2015 |
| Abstract : Basauri-Molina_2015_Chem.Commun.(Camb)_51_6792 |
| ESTHER : Basauri-Molina_2015_Chem.Commun.(Camb)_51_6792 |
| PubMedSearch : Basauri-Molina_2015_Chem.Commun.(Camb)_51_6792 |
| PubMedID: 25786894 |
| Gene_locus related to this paper: canar-LipB , fusso-cutas |