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Inhibitor Report for: Rhc80267

Inhibitor of DAGL but inhibits also ABHD6 HSL MGLL and CES1. However Baggelaar et al.2013 found n o inhibition of DAGLA


General
Type Carbamate
Chemical_Nomenclature (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
Canonical SMILES C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1
InChI InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
InChIKey RXSVYGIGWRDVQC-UHFFFAOYSA-N
Other name(s) Rhc 80267 ; RHC-80267 ; U 57908 ; 83654-05-1 ; Rg 80267 ; 1,6-Bis(cyclohexyloximinocarbonyl)hexane
________________________________________________________________________________________________
MW|394.50
Formula|C20H34N4O4
CAS_number|
PubChem|5063
UniChem|RXSVYGIGWRDVQC-UHFFFAOYSA-N
IUPHAR|5255
Wikipedia|


References:
Search PubMed for references concerning: Rhc80267

4 more
    Title: Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy
    Ma L, Wang L, Yang F, Meng XD, Wu C, Ma H, Jiang W
    Ref: CNS Neurosci Ther, 20:905, 2014 : PubMed

            

    Title: Assay and inhibition of diacylglycerol lipase activity
    Johnston M, Bhatt SR, Sikka S, Mercier RW, West JM, Makriyannis A, Gatley SJ, Duclos RI, Jr.
    Ref: Bioorganic & Medicinal Chemistry Lett, 22:4585, 2012 : PubMed

            

    Title: Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
    Hoover HS, Blankman JL, Niessen S, Cravatt BF
    Ref: Bioorganic & Medicinal Chemistry Lett, 18:5838, 2008 : PubMed