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Inhibitor Report for: Rocuronium

neuromuscular non depolarising blocking drug, aminosteroids related to pancuronium and vecuronium, aminosteroid. Rocuronium has an intermediate duration of action and produces its maximum of effect within 2 minutes. Rocuronium can be rapidly reversed with sugammadex, so this drug combination offers an alternative to suxamethonium. Sugammadex, unlike neostigmine, does not inhibit acetylcholinesterase so cholinergic effects are not produced and co-administration of an antimuscarinic agent (glycopyrronium bromide or atropine) is not needed


General
Type Neuromuscular Nondepolarizing Agents, Aminosteroid, Drug, Not A/B H target, Morpholine
Chemical_Nomenclature [(2R,3R,5R,8R,9R,10S,13S,14R,16R,17S) -3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16- (1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl) -2,3,4,5,6,7,8,9,11,12,14,15,16,17 -tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Canonical SMILES CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C
InChI InChI=1S/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35/h5,23-30,36H,1,6-21H2,2-4H3/q+1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-/m0/s1
InChIKey YXRDKMPIGHSVRX-OOJCLDBCSA-N
Other name(s) Zemuron ; ORG 9426
________________________________________________________________________________________________
MW|529.774
Formula|C32H53N2O4
CAS_number|119302-91-9
PubChem|441290
UniChem|YXRDKMPIGHSVRX-OOJCLDBCSA-N
IUPHAR|4003
Wikipedia|Rocuronium_bromide

Target

References:
Search PubMed for references concerning: Rocuronium

24 more
    Title: Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine
    Jones RK, Caldwell JE, Brull SJ, Soto RG
    Ref: Anesthesiology, 109:816, 2008 : PubMed

            

    Title: Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine
    Sacan O, White PF, Tufanogullari B, Klein K
    Ref: Anesthesia & Analgesia, 104:569, 2007 : PubMed

            

    Title: Clinical pharmacokinetics of the newer neuromuscular blocking drugs
    Atherton DP, Hunter JM
    Ref: Clinical Pharmacokinetics, 36:169, 1999 : PubMed