SCHEMBL15272467
General
Type : Trifluoro,Piperidine,Urea derivative
Chemical_Nomenclature : 1-(1-propanoylpiperidin-4-yl)-3-[1-(trifluoromethoxy)cyclohexa-2,4-dien-1-yl]urea
Canonical SMILES : CCC(=O)N1CCC(CC1)NC(=O)NC2(CC=CC=C2)OC(F)(F)F
InChI : InChI=1S\/C16H22F3N3O3\/c1-2-13(23)22-10-6-12(7-11-22)20-14(24)21-15(25-16(17,18)19)8-4-3-5-9-15\/h3-5,8,12H,2,6-7,9-11H2,1H3,(H2,20,21,24)
InChIKey : YTBWXRXIRPVHMH-UHFFFAOYSA-N
Other name(s) :
MW : 361.36
Formula : C16H22F3N3O3
CAS_number :
PubChem : 89815618
UniChem : YTBWXRXIRPVHMH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SCHEMBL15272467 ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX2
References (2)
| Title : Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK - Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| Author(s) : Luo Y , Wu MY , Deng BQ , Huang J , Hwang SH , Li MY , Zhou CY , Zhang QY , Yu HB , Zhao DK , Zhang G , Qin L , Peng A , Hammock BD , Liu JY |
| Ref : Proc Natl Acad Sci U S A , 116 :5154 , 2019 |
| Abstract : Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| ESTHER : Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| PubMedSearch : Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| PubMedID: 30804206 |
| Title : Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice - Zhou_2016_Cell.Tissue.Res_363_399 |
| Author(s) : Zhou Y , Sun GY , Liu T , Duan JX , Zhou HF , Lee KS , Hammock BD , Fang X , Jiang JX , Guan CX |
| Ref : Cell Tissue Research , 363 :399 , 2016 |
| Abstract : Zhou_2016_Cell.Tissue.Res_363_399 |
| ESTHER : Zhou_2016_Cell.Tissue.Res_363_399 |
| PubMedSearch : Zhou_2016_Cell.Tissue.Res_363_399 |
| PubMedID: 26310139 |