SCHEMBL15589912
General
Type : Benzothiazol,Sulfur Compound,Morpholine,Oxadiazol,Sulfonyl
Chemical_Nomenclature : 5-[[5-[methylsulfonyl-[6-[4-(morpholine-4-carbonyl)phenyl]-1,3-benzothiazol-2-yl]methyl]-1,3,4-oxadiazol-2-yl]methyl]-1,3-thiazolidine-2,4-dione
Canonical SMILES : CS(=O)(=O)C(C1=NN=C(O1)CC2C(=O)NC(=O)S2)C3=NC4=C(S3)C=C(C=C4)C5=CC=C(C=C5)C(=O)N6CCOCC6
InChI : InChI=1S\/C26H23N5O7S3\/c1-41(35,36)21(23-30-29-20(38-23)13-19-22(32)28-26(34)40-19)24-27-17-7-6-16(12-18(17)39-24)14-2-4-15(5-3-14)25(33)31-8-10-37-11-9-31\/h2-7,12,19,21H,8-11,13H2,1H3,(H,28,32,34)
InChIKey : VTGUKEFEIRIGHJ-UHFFFAOYSA-N
Other name(s) :
MW : 613.7
Formula : C26H23N5O7S3
CAS_number :
PubChem : 72944619
UniChem : VTGUKEFEIRIGHJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SCHEMBL15589912 ligand of proteins in family: Lipoprotein_Lipase
Stucture :
Protein : human-LIPG
References (1)
| Title : Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase - Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| Author(s) : Kim SH , Johnson JA , Jiang J , Parkhurst B , Phillips M , Pi Z , Qiao JX , Tora G , Ye Chen A , Liu E , Yin X , Yang R , Zhao L , Taylor DS , Basso M , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 29 :1918 , 2019 |
| Abstract : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| ESTHER : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedSearch : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedID: 31176700 |
| Gene_locus related to this paper: human-LIPG |