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Inhibitor Report for: SCHEMBL19834081

human-MAGLL IC50 15nM


General
Type Piperidine
Chemical_Nomenclature 6-[4-[(2-chloro-4-fluorophenoxy)methyl]piperidine-1-carbonyl]-4H-1,4-benzoxazin-3-one
Canonical SMILES C1CN(CCC1COC2=C(C=C(C=C2)F)Cl)C(=O)C3=CC4=C(C=C3)OCC(=O)N4
InChI InChI=1S/C21H20ClFN2O4/c22-16-10-15(23)2-4-18(16)28-11-13-5-7-25(8-6-13)21(27)14-1-3-19-17(9-14)24-20(26)12-29-19/h1-4,9-10,13H,5-8,11-12H2,(H,24,26)
InChIKey UUUUFICXTVCJQV-UHFFFAOYSA-N
Other name(s) XPD
________________________________________________________________________________________________
MW|418.8
Formula|C21H20ClFN2O4
CAS_number|
PubChem|134226591
UniChem|UUUUFICXTVCJQV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | SCHEMBL19834081 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture | 1 structure: 7L4T: Crystal structure of human monoacylglycerol lipase in complex with compound SCHEMBL19834081
Protein | human-MGLL

References:
Search PubMed for references concerning: SCHEMBL19834081
    Title: Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety
    Ikeda S, Sugiyama H, Tokuhara H, Murakami M, Nakamura M, Oguro Y, Aida J, Morishita N, Sogabe S and Kamata M <9 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2021 : PubMed