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Inhibitor Report for: SUMO1-EIL

The small ubiquitin-like protein modifier SUMO1 interacts with an armlike structure in DPP8 DPP9, leading to allosteric activation of the peptidase. SUMO1-EIL noncompetitive Inhibitor of DPP8 and DPP9 - E67 interacting loop (EIL)


General
Type Peptide
Chemical_Nomenclature SLRFLFEGQRIADNH
Canonical SMILES
InChI
InChIKey
Other name(s) SLRFLFEGQRIADNH ; E67 interacting loop (EIL) ; BDBM213827
________________________________________________________________________________________________
MW|1803
Formula|C80H123N25O23
CAS_number|
PubChem|124220806
UniChem|
IUPHAR|
Wikipedia|

Target
Families | SUMO1-EIL ligand of proteins in family: DPP4N_Peptidase_S9
Stucture | 1 structure: 6TRW: Crystal structure of DPP8 in complex with the EIL peptide (SLRFLFEGQRIADNH)
Protein | human-DPP8, human-DPP9

References:
Search PubMed for references concerning: SUMO1-EIL
    Title: The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9
    Pilla E, Kilisch M, Lenz C, Urlaub H, Geiss-Friedlander R
    Ref: Journal of Biological Chemistry, 288:32787, 2013 : PubMed