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Inhibitor Report for: Soman

Nerve agent GD


General
Type Chemical Warfare Agent, Organophosphate, Nerve Agent G-series, Derivative of Soman
Chemical_Nomenclature 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane
Canonical SMILES CC(C(C)(C)C)OP(=O)(C)F
InChI InChI=1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3
InChIKey GRXKLBBBQUKJJZ-UHFFFAOYSA-N
Other name(s) Pinacolylmethylphosphonofluoridate ; Pinacolyloxymethylphosphorylfluoride ; Methylphosphonofluoridic acid, 1,2,2-trimethylpropyl ester ; GD ; ZINC000038494900
________________________________________________________________________________________________
MW|182.19
Formula|C7H16FO2P
CAS_number|96-64-0
PubChem|7305
UniChem|GRXKLBBBQUKJJZ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Soman

Target
Families | Soman ligand of proteins in family: BCHE, ACHE, PAF-Acetylhydrolase, Carb_B_Chordata, Carboxypeptidase_S10
Stucture | 14 structures (e.g. : 1SOM, 6WVO, 6WVC... more)
Protein | torca-ACHE, human-BCHE, human-PLA2G7, human-CES1, human-CTSA

References:
Search PubMed for references concerning: Soman

75 more
    Title: Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents
    Jacquet P, Remy B, Bross RPT, van Grol M, Gaucher F, Chabriere E, De Koning MC, Daude D
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning
    Saxena A, Maxwell DM, Quinn DM, Radic Z, Taylor P, Doctor BP
    Ref: Biochemical Pharmacology, 54:269, 1997 : PubMed

            

    Title: Enzymes as pretreatment drugs for organophosphate toxicity
    Doctor BP, Raveh L, Wolfe AD, Maxwell DM, Ashani Y
    Ref: Neurosci Biobehav Rev, 15:123, 1991 : PubMed