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Inhibitor Report for: Spermine

Spermine is a spermidine-derived biogenic polyamine polyazaalkane found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. interactant with many enzymes


General
Type Natural
Chemical_Nomenclature N,N'-bis(3-aminopropyl)butane-1,4-diamine
Canonical SMILES C(CCNCCCN)CNCCCN
InChI InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
Other name(s) musculamine ; neuridine ; gerontine ; CHEMBL23194 ; CHEBI:15746 ; SCHEMBL14965 ; ZINC1532734
________________________________________________________________________________________________
MW|202.34
Formula|C10H26N4
CAS_number|71-44-3
PubChem|1103
UniChem|PFNFFQXMRSDOHW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Spermine ligand of proteins in family: S9N_PREPL_Peptidase_S9
Stucture | 3 structures: 7YWS, 7YX7, 7OB1
Protein | 9gamm-b3vi58

References:
Search PubMed for references concerning: Spermine
    Title: First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine
    Petrenko DE, Timofeev VI, Britikov VV, Britikova EV, Kleymenov SY, Vlaskina AV, Kuranova IP, Mikhailova AG, Rakitina TV
    Ref: Biology (Basel), 10:, 2021 : PubMed

            

    Title: Regulation of prolyl oligopeptidase activity in regenerating rat liver
    Yamakawa N, Shimeno H, Soeda S, Nagamatsu A
    Ref: Biochimica & Biophysica Acta, 1199:279, 1994 : PubMed

            

    Title: Effects of polyamines on proline endopeptidase activity in rat brain
    Soeda S, Yamakawa N, Shimeno H, Nagamatsu A
    Ref: Journal of Neurochemistry, 46:1304, 1986 : PubMed