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Inhibitor Report for: Tabun

nerve gas GA On December 23. 1936 Dr. Gerhard Schrader of I.G. FarBen in Germany accidentally isollated ethyl N,N-dimelhylphosphoramidocyanidate) while engaged in his progrm to develop new insecticides since 1934. It was a colorless to brown liquid with a fainty fruity odor. Controlled animal laboratory studies revealed that death could occur within 20 min of exposure. In January 1937. Schrader and his assistant were the first to experierience the effects on humans. A smalldrop spilled on a laboratory bench caused both of them to experience miosis and difficulty in breathing. The chemical was quickly recognized as a new, more deadly. chemical warfare agent. It was inilially designated as Le-lOO, and later as Trilon-83, Tabun. The United States, designated it GA for German Agent A. The first Tabun production was at Elberfeld. Relocated inn 1940 Dyhemfurth. Tabun was apparenlly tested on German death camp inmates

Type Cyanide, Chemical Warfare Agent, Organophosphate, Nerve Agent G-series
Chemical_Nomenclature [dimethylamino(ethoxy)phosphoryl]formonitrile
Canonical SMILES CCOP(=O)(C#N)N(C)C
InChI InChI=1S/C5H11N2O2P/c1-4-9-10(8,5-6)7(2)3/h4H2,1-3H3
Other name(s) Ethyl-N-dimethylphosphoramidocyanidate ; Dimethylamidoethoxyphosphoryl cyanide ; d7 ; Gelan ; Trilon 83 ; Trilon-83 ; GA ; Le-100

Families | Tabun ligand of proteins in family: ACHE, BCHE
Stucture | 25 structures (e.g. : 7BFT, 7BFN, 6WUV... more)
Protein | mouse-ACHE

Search PubMed for references concerning: Tabun

16 more
    Title: Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents
    Jacquet P, Remy B, Bross RPT, van Grol M, Gaucher F, Chabriere E, De Koning MC, Daude D
    Ref: Int J Mol Sci, 22:, 2021 : PubMed


    Title: Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
    Kovarik Z, Macek Hrvat N, Kalisiak J, Katalinic M, Sit RK, Zorbaz T, Radic Z, Fokin VV, Sharpless KB, Taylor P
    Ref: Toxicol Appl Pharmacol, 372:40, 2019 : PubMed


    Title: Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase
    Kovarik Z, Kalisiak J, Hrvat NM, Katalinic M, Zorbaz T, Zunec S, Green C, Radic Z, Fokin VV and Taylor P <1 more author(s)>
    Ref: Chemistry, 25:4100, 2019 : PubMed