Inhibitor Report for: Tacrine-Donepezil-hybrid3

IC50=6.0 nM

General

Type		Derivative of Tacrine, Derivative of Donepezil
Chemical_Nomenclature		N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide
Canonical SMILES		C1CCC2=NC3=CC=CC=C3C(=C2C1)NCC(=O)NCCC4CCN(CC4)CC5=CC=CC=C5
InChI		InChI=1S/C29H36N4O/c34-28(30-17-14-22-15-18-33(19-16-22)21-23-8-2-1-3-9-23)20-31-29-24-10-4-6-12-26(24)32-27-13-7-5-11-25(27)29/h1-4,6,8-10,12,22H,5,7,11,13-21H2,(H,30,34)(H,31,32)
InChIKey		AYESZVAJFBYQHK-UHFFFAOYSA-N
Other name(s)		CHEMBL486901 ; Tacrine-E2020 analog 3 ; BDBM8979 ; N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide

________________________________________________________________________________________________

MW	\|	456.63
Formula	\|	C29H36N4O
CAS_number	\|
PubChem	\|	10004239
UniChem	\|	AYESZVAJFBYQHK-UHFFFAOYSA-N
IUPHAR	\|
Wikipedia	\|

Target

Families

Tacrine-Donepezil-hybrid3 ligand of proteins in family: ACHE

References:

Search PubMed for references concerning: Tacrine-Donepezil-hybrid3

Title:

Shao D, Zou C, Luo C, Tang X, Li Y

Ref:

PubMed