Tacrine-Resveratrol-12
Association of the structural features of the cholinesterase inhibitor drug tacrine with that of resveratrol, which is known for its antioxidant and anti-neuroinflammatory activities. IC50 AChE= 8.8 microM
General
Type : Multitarget,Antioxidant,Derivative of Tacrine
Chemical_Nomenclature : 5-[(E)-2-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]phenyl]ethenyl]benzene-1,3-diol
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NC4=CC=C(C=C4)C=CC5=CC(=CC(=C5)O)O
InChI : InChI=1S\/C27H23ClN2O2\/c28-19-9-12-24-26(15-19)30-25-4-2-1-3-23(25)27(24)29-20-10-7-17(8-11-20)5-6-18-13-21(31)16-22(32)14-18\/h5-16,31-32H,1-4H2,(H,29,30)\/b6-5+
InChIKey : XZNDKAUHJQWCTR-AATRIKPKSA-N
Other name(s) : (E)-5-(4-((6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)styryl)benzene-1,3-diol,CHEMBL4081795
MW : 442.94
Formula : C27H23ClN2O2
CAS_number :
PubChem : 132278810
UniChem : XZNDKAUHJQWCTR-AATRIKPKSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
| Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
| Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
| Abstract : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| ESTHER : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedID: 28064079 |