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Inhibitor Report for: Terephthalic-acid

product of hydrolysis of Polyethylene-terephthalate. Polyethylene terephthalate is the most common thermoplastic polymer resin of the polyester family and is used in fibers for clothing, containers for liquids and foods. Terephthalate(2-) is the dianion obtained by the deprotonation of the carboxy groups of terephthalic acid. Degradation of PET using hydrolytic enzymes leads to the release of hydrolysis products such as BHET (bis(2-hydroxyethyl) terephthalate), MHET (mono-(2-hydroxyethyl) terephthalic acid), TPA (terephthalic acid) and EG (ethylene glycol)


General
Type Terephthalate, Phthalate
Chemical_Nomenclature terephthalic acid
Canonical SMILES C1=CC(=CC=C1C(=O)O)C(=O)O
InChI InChI=1S/C8H6O4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h1-4H,(H,9,10)(H,11,12)
InChIKey KKEYFWRCBNTPAC-UHFFFAOYSA-N
Other name(s) TPA ; Terephthalate ; P-Phthalic acid ; 1,4-Benzenedicarboxylic acid ; Benzene-1,4-dicarboxylic acid ; P-Dicarboxybenzene ; 1,4-Benzenedicarboxylate ; 1,4-Benzenedicarboxylic acid, ion(2-)
________________________________________________________________________________________________
MW|166.13
Formula|C8H6O4
CAS_number|100-21-0
PubChem|7489
UniChem|KKEYFWRCBNTPAC-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Terephthalic-acid ligand of proteins in family: Polyesterase-lipase-cutinase, Tannase
Protein | idesa-peth, idesa-mheth

References:
Search PubMed for references concerning: Terephthalic-acid

3 more
    Title: Characterization and engineering of a plastic-degrading aromatic polyesterase
    Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R and Beckham GT <11 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 115:E4350, 2018 : PubMed

            

    Title: New insights into the function and global distribution of polyethylene terephthalate (PET) degrading bacteria and enzymes in marine and terrestrial metagenomes
    Danso D, Schmeisser C, Chow J, Zimmermann W, Wei R, Leggewie C, Li X, Hazen T, Streit WR
    Ref: Applied Environmental Microbiology, 84:e2773, 2018 : PubMed

            

    Title: Structural insight into catalytic mechanism of PET hydrolase
    Han X, Liu W, Huang JW, Ma J, Zheng Y, Ko TP, Xu L, Cheng YS, Chen CC, Guo RT
    Ref: Nat Commun, 8:2106, 2017 : PubMed