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Inhibitor Report for: Trichlorfon~Metrifonate

Anthelmintic is used for treating domestic animals for control of internal parasites and has been tested in patients with Alzheimer's disease. Metrifonate is slowly converted in the body by a nonenzymatic process to the long-acting cholinesterase inhibitor Dichlorvos


General
Type Organophosphate, Insecticide, Anthelmintic
Chemical_Nomenclature (2,2,2-Trichloro-1-hydroxyethyl)-phosphonic acid dimethyl ester
Canonical SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC
InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
InChIKey NFACJZMKEDPNKN-UHFFFAOYSA-N
Other name(s) Trichlorphon ; Promem ; Metriphonate ; Metrifonate ; Chlorofos ; Dylox ; Dipterex ; Proxol ; Neguvon ; MFT
________________________________________________________________________________________________
MW|257.44
Formula|C4H8Cl3O4P
CAS_number|52-68-6
PubChem|5853
UniChem|NFACJZMKEDPNKN-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Metrifonate

Target
Families | Trichlorfon~Metrifonate ligand of proteins in family: BCHE, ACHE

References:
Search PubMed for references concerning: Trichlorfon~Metrifonate

62 more
    Title: Modulation of dopaminergic neurotransmission induced by sublethal Doses of the organophosphate trichlorfon in cockroaches
    Daiane Stu Rmer G, de Freitas TC, de Avila Heberle M, de Assis DR, Vinade L, Batista Pereira A, Luis Franco J, Andre Dal Belo C
    Ref: Ecotoxicology & Environmental Safety, 109C:56, 2014 : PubMed

            

    Title: Effects of combined chronic nimodipine and acute metrifonate treatment on spatial and avoidance behavior
    Riekkinen M, Schmidt B, Kuitunen J, Riekkinen P
    Ref: European Journal of Pharmacology, 322:1, 1997 : PubMed

            

    Title: Human mortality in organophosphate poisonings
    Yamashita M, Tanaka J, Ando Y
    Ref: Vet Hum Toxicol, 39:84, 1997 : PubMed