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Inhibitor Report for: Triflupromazine

Dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent


General
Type Phenothiazine, Sulfur Compound, Trifluoro, Not A/B H target
Chemical_Nomenclature N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
Canonical SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F
InChI InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
InChIKey XSCGXQMFQXDFCW-UHFFFAOYSA-N
Other name(s) triflupromazine ; Fluopromazine ; Trifluopromazine ; Vesprin ; Adazine ; CHEBI:9711 ; CHEMBL570 ; SCHEMBL44085 ; ZINC538507
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MW|352.4
Formula|C18H19F3N2S
CAS_number|146-54-3
PubChem|5568
UniChem|XSCGXQMFQXDFCW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Triflupromazine

1 more
    Title: Inactivation of cholinesterase induced by chlorpromazine cation radicals
    Muraoka S, Miura T
    Ref: Pharmacol Toxicol, 92:100, 2003 : PubMed

            

    Title: Inhibition of butyrylcholinesterase by phenothiazine derivatives
    Debord J, Merle L, Bollinger JC, Dantoine T
    Ref: J Enzyme Inhib Med Chem, 17:197, 2002 : PubMed

            

    Title: Central and peripheral actions of anticholinergic drugs when administered with triflupromazine
    Brimblecombe RW, Green DM, Aldous FA, Thompson PB
    Ref: Neuropharmacology, 10:93, 1971 : PubMed