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Inhibitor Report for: VX

The V-series weapons, including VX, are the most highly toxic chemical warfare nerve agents. Nerve agents are compounds that have the capacity to inactivate the enzyme acetylcholinesterase (AChE). The first compounds to be synthesized were known as the G agents (G stands for German): tabun (GA), sarin (GB), and soman (GD). These compounds were discovered and synthesized by German scientists, led by Dr Gerhard Schrader, during World War II. The V agents are part of the group of persistent agents, which are nerve agents that can remain on skin, clothes, and other surfaces for long periods of time. The consistency of these agents is similar to oil; thus, the inhalation hazard is less than with the G agents. This consistency thus renders them toxic mainly by dermal exposures. The British first synthesized O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) in 1954.


General
Type Chemical Warfare Agent, Organophosphate, Nerve Agent V-series
Chemical_Nomenclature N-[2-[ethoxy(methyl)phosphoryl]sulfanylethyl]-N-propan-2-ylpropan-2-amine
Canonical SMILES CCOP(=O)(C)SCCN(C(C)C)C(C)C
InChI InChI=1S/C11H26NO2PS/c1-7-14-15(6,13)16-9-8-12(10(2)3)11(4)5/h10-11H,7-9H2,1-6H3
InChIKey JJIUCEJQJXNMHV-UHFFFAOYSA-N
Other name(s) O-ethyle methylphosphonothiolate, S-2 diiso propylaminoethyl ; O-ehtyl-S2-diisopropylaminoethyl methyl-phosphonothinate ; methylthiophosphorous acid O-ethyl-S-2-diisopropyl-aminoethylester ; EDIM ; VX (van) ; Tx 60 ; CCRIS 3351 ; HSDB 6459 ; BRN 1949015 ; NISTC50782699 ; EA 1701 ; Ethyl S-dimethylaminoethyl methylphosphonothiolate ; Ethyl-S-diisopropylaminoethyl methylthiophosphonate ; MPT ; methylphosphonothioic acid
________________________________________________________________________________________________
MW|267.37
Formula|C11H26NO2PS
CAS_number|50782-69-9
PubChem|39793
UniChem|JJIUCEJQJXNMHV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|VX_(nerve_agent)

Target
Families | VX ligand of proteins in family: ACHE, BCHE
Stucture | 19 structures (e.g. : 1VXO, 1VXR, 7R3C... more)
Protein | torca-ACHE, human-ACHE, mouse-ACHE, human-BCHE

References:
Search PubMed for references concerning: VX

58 more
    Title: Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents
    Jacquet P, Remy B, Bross RPT, van Grol M, Gaucher F, Chabriere E, De Koning MC, Daude D
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: [Therapy of domestic animals affected by alkylphosphates]
    Benes J, Hrusovsky J, Proksova M
    Ref: Vet Med, 24:623, 1979 : PubMed

            

    Title: Active-site catalytic efficiency of acetylcholinesterase molecular forms in Electrophorus, torpedo, rat and chicken
    Vigny M, Bon S, Massoulie J, Leterrier F
    Ref: European Journal of Biochemistry, 85:317, 1978 : PubMed