Valnoctamide
Valnoctamide has been used in trials studying the treatment of Mania and Schizoaffective Disorder, Manic Type
General
Type : Not A\/B H target
Chemical_Nomenclature : 2-ethyl-3-methylpentanamide
Canonical SMILES : CCC(C)C(CC)C(=O)N
InChI : InChI=1S\/C8H17NO\/c1-4-6(3)7(5-2)8(9)10\/h6-7H,4-5H2,1-3H3,(H2,9,10)
InChIKey : QRCJOCOSPZMDJY-UHFFFAOYSA-N
Other name(s) : Valmethamide,2-Ethyl-3-methylpentanamide,Nirvanil,SCHEMBL387435,CHEMBL1075733,CHEBI:134767,DB13099
MW : 143.23
Formula : C8H17NO
CAS_number : 4171-13-5
PubChem : 20140
UniChem : QRCJOCOSPZMDJY-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Valnoctamide ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX1
References (4)
| Title : Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition - Rosa_2016_Xenobiotica_46_1076 |
| Author(s) : Rosa M , Bonnaillie P , Chanteux H |
| Ref : Xenobiotica , 46 :1076 , 2016 |
| Abstract : Rosa_2016_Xenobiotica_46_1076 |
| ESTHER : Rosa_2016_Xenobiotica_46_1076 |
| PubMedSearch : Rosa_2016_Xenobiotica_46_1076 |
| PubMedID: 26936324 |
| Title : Clinically significant pharmacokinetic drug interactions with carbamazepine. An update - Spina_1996_Clin.Pharmacokinet_31_198 |
| Author(s) : Spina E , Pisani F , Perucca E |
| Ref : Clinical Pharmacokinetics , 31 :198 , 1996 |
| Abstract : Spina_1996_Clin.Pharmacokinet_31_198 |
| ESTHER : Spina_1996_Clin.Pharmacokinet_31_198 |
| PubMedSearch : Spina_1996_Clin.Pharmacokinet_31_198 |
| PubMedID: 8877250 |
| Title : Carbamazepine-valnoctamide interaction in epileptic patients: in vitro\/in vivo correlation - Pisani_1993_Epilepsia_34_954 |
| Author(s) : Pisani F , Haj-Yehia A , Fazio A , Artesi C , Oteri G , Perucca E , Kroetz DL , Levy RH , Bialer M |
| Ref : Epilepsia , 34 :954 , 1993 |
| Abstract : Pisani_1993_Epilepsia_34_954 |
| ESTHER : Pisani_1993_Epilepsia_34_954 |
| PubMedSearch : Pisani_1993_Epilepsia_34_954 |
| PubMedID: 8104783 |
| Title : Impairment of carbamazepine-10, 11-epoxide elimination by valnoctamide, a valpromide isomer, in healthy subjects - Pisani_1992_Br.J.Clin.Pharmacol_34_85 |
| Author(s) : Pisani F , Fazio A , Artesi C , Oteri G , Spina E , Tomson T , Perucca E |
| Ref : British Journal of Clinical Pharmacology , 34 :85 , 1992 |
| Abstract : Pisani_1992_Br.J.Clin.Pharmacol_34_85 |
| ESTHER : Pisani_1992_Br.J.Clin.Pharmacol_34_85 |
| PubMedSearch : Pisani_1992_Br.J.Clin.Pharmacol_34_85 |
| PubMedID: 1352988 |