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Inhibitor Report for: Valpromide

also inhibitor of Limonene-1,2-epoxide hydrolase (not alpha/beta hydrolase) Valpromide is a prodrug of valproic acid. Valpromide has been used as an antiepileptic and antipsychotic drug. Inhibitor of microsomal but not soluble epoxyde hydrolases


General
Type Drug, Carboxamide
Chemical_Nomenclature 2-propylpentanamide
Canonical SMILES CCCC(CCC)C(=O)N
InChI InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)
InChIKey OMOMUFTZPTXCHP-UHFFFAOYSA-N
Other name(s) Depamide ; 2-PROPYLPENTANAMIDE ; Dipropylacetamide ; 2-Propylvaleramide ; Valpramide
________________________________________________________________________________________________
MW|143.22
Formula|C8H17NO
CAS_number|2430-27-5
PubChem|71113
UniChem|OMOMUFTZPTXCHP-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Valpromide ligand of proteins in family: Epoxide_hydrolase
Stucture | 2 structures: 3G0I, 2CJP
Protein | soltu-3epoxy, aspni-hyl1, human-EPHX1

References:
Search PubMed for references concerning: Valpromide

4 more
    Title: Structural insights into human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations
    Saenz-Mendez P, Katz A, Perez-Kempner ML, Ventura ON, Vazquez M
    Ref: Proteins, 85:720, 2017 : PubMed

            

    Title: Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage
    Reetz MT, Bocola M, Wang LW, Sanchis J, Cronin A, Arand M, Zou J, Archelas A, Bottalla AL and Mowbray SL <1 more author(s)>
    Ref: Journal of the American Chemical Society, 131:7334, 2009 : PubMed

            

    Title: X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes
    Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M
    Ref: Protein Science, 15:1628, 2006 : PubMed