Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Vinblastine

Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine is an antineoplastic agent. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. It inhibits AADAC and CES2 but not CES1



General
Type: Alkaloid
Chemical_Nomenclature: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
Canonical SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChIKey: JXLYSJRDGCGARV-CFWMRBGOSA-N
Other name(s): Vinblastin ; Vincaleucoblastin ; Vinblastinum ; Vincoblastine ; Vinblastina ; Velban
MW: 810.98
Formula: C46H58N4O9
CAS_number: 865-21-4
PubChem: 13342
IUPHAR:
Wikipedia: Vinblastine

Target families
Vinblastine ligand of proteins in family: Arylacetamide_deacetylase, Carb_B_Chordata
No structure

Protein target

References
Search PubMed for references concerning: Vinblastine
    Title: Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
    Hirosawa K, Fukami T, Tashiro K, Sakai Y, Kisui F, Nakano M, Nakajima M
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, :, 2021 : PubMed

            

    Title: Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase
    Shimizu M, Fukami T, Nakajima M, Yokoi T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42:1103, 2014 : PubMed