Inhibitor Report for: Z-Pro-Prolinal-derived General
Type Benzyloxycarbonyl , Piperidine , Peptide , Pyrrolidine , Carboxamide , Carbamate Chemical_Nomenclature benzyl (2S)-2-[(2S)-2-(hydroxymethyl)piperidine-1-carbonyl]pyrrolidine-1-carboxylate Canonical SMILES C1CCN(C(C1)CO)C(=O)C2CCCN2C(=O)OCC3=CC=CC=C3 InChI InChI=1S/C19H26N2O4/c22-13-16-9-4-5-11-20(16)18(23)17-10-6-12-21(17)19(24)25-14-15-7-2-1-3-8-15/h1-3,7-8,16-17,22H,4-6,9-14H2/t16-,17-/m0/s1 InChIKey YRBBTAYHOWGHHS-IRXDYDNUSA-N Other name(s) 2xdw
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Target
Families | Z-Pro-Prolinal-derived ligand of proteins in family: S9N_PPCE_Peptidase_S9 Stucture | 1 structure : 2XDW : Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide Protein | pig-ppce
References:
Title: Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide
Racys DT , Rea D , Fulop V , Wills M
Ref: Bioorganic & Medicinal Chemistry, 18 :4775, 2010 : PubMed Abstract ESTHER: Racys_2010_Bioorg.Med.Chem_18_4775 PubMedSearch: Racys 2010 Bioorg.Med.Chem 18 4775 PubMedID: 20627594 Gene_locus related to this paper: pig-ppce Inhibitor(s) related to this paper: Z-Pro-Prolinal-derived Abstract
A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings.