ZAI
Reversible inhibitor of insect AChE
General
Type : Acridine,Derivative of Tacrine
Chemical_Nomenclature : 1,2,3,4,-tetrahydro-N-(3-iodophenyl methyl)-9-acridinamine
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCC4=CC(=CC=C4)I
InChI : InChI=1S\/C20H19IN2\/c21-15-7-5-6-14(12-15)13-22-20-16-8-1-3-10-18(16)23-19-11-4-2-9-17(19)20\/h1,3,5-8,10,12H,2,4,9,11,13H2,(H,22,23)
InChIKey : ZUCWQTWGZGIYPV-UHFFFAOYSA-N
Other name(s) : 9-(3-iodophenyl)-1,2,3,4-tetrahydroacridine,9-(3-iodophenyl)-tacrine
MW : 414.283
Formula : C20H19N2I
CAS_number :
PubChem : 448167
UniChem : ZUCWQTWGZGIYPV-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides - Nachon_2020_Molecules_25_1198 |
| Author(s) : Nachon F , Rosenberry TL , Silman I , Sussman JL |
| Ref : Molecules , 25 :1198 , 2020 |
| Abstract : Nachon_2020_Molecules_25_1198 |
| ESTHER : Nachon_2020_Molecules_25_1198 |
| PubMedSearch : Nachon_2020_Molecules_25_1198 |
| PubMedID: 32155891 |
| Gene_locus related to this paper: drome-ACHE |
| Title : Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors - Harel_2000_Protein.Sci_9_1063 |
| Author(s) : Harel M , Kryger G , Rosenberry TL , Mallender WD , Lewis T , Fletcher RJ , Guss JM , Silman I , Sussman JL |
| Ref : Protein Science , 9 :1063 , 2000 |
| Abstract : Harel_2000_Protein.Sci_9_1063 |
| ESTHER : Harel_2000_Protein.Sci_9_1063 |
| PubMedSearch : Harel_2000_Protein.Sci_9_1063 |
| PubMedID: 10892800 |
| Gene_locus related to this paper: drome-ACHE |