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Inhibitor Report for: sEH-LTA4H-14

Multitarget anti-inflammatory drug Compound 14: dual inhibitor of soluble epoxide hydrolase (sEH) and LTA4 hydrolase (Leukotriene A-4 hydrolase LTA4H) with sub-micromolar activity towards both targets IC50 sEH 0.3 +/- 0.1 muM IC50 LTA4H 0.2 +/- 0.1 muM


General
Type Urea derivative, LTA4-hydrolase-inhibitor, Multitarget, Sulfur Compound
Chemical_Nomenclature 2-(4-(benzo[d]thiazol-2-yloxy)-2-fluorophenyl)-N-(4-fluorophenethyl)acetamide
Canonical SMILES C1=CC=CC2=C1N=C(S2)OC3=CC(=C(C=C3)CC(=O)N(CCC4=CC=C(C=C4)F)[H])F
InChI InChI=1S/C23H18F2N2O2S/c24-17-8-5-15(6-9-17)11-12-26-22(28)13-16-7-10-18(14-19(16)25)29-23-27-20-3-1-2-4-21(20)30-23/h1-10,14H,11-13H2,(H,26,28)
InChIKey PQOJWVHLJYMILK-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|424.11
Formula|C23H18F2N2O2S
CAS_number|
PubChem|
UniChem|PQOJWVHLJYMILK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | sEH-LTA4H-14 ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX2

References:
Search PubMed for references concerning: sEH-LTA4H-14
    Title: Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase
    Hiesinger K, Schott A, Kramer JS, Blocher R, Witt F, Wittmann SK, Steinhilber D, Pogoryelov D, Gerstmeier J and Proschak E <1 more author(s)>
    Ref: ACS Med Chem Lett, 11:298, 2020 : PubMed