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Kinetic parameters for mutation D131N_human-ACHE


MoleculeKmKcatExp. conditionsReference
3,3-dimethylbutylthioacetate 300 & 50 uM 55000 & 10000/min 50mM NaPhosphate pH8 Kronman_1994_J.Biol.Chem_269_27819
Acetylthiocholine 140 & 10 uM 390000 & 40000/min 50mM NaPhosphate pH8 Kronman_1994_J.Biol.Chem_269_27819


MoleculeKiKsiIc50Exp. conditionsSubstrateReference
Edrophonium 2.1 & 0.3 uM - - 50mM NaPhosphate pH8 3.3-dimethylbutylthioacetate Kronman_1994_J.Biol.Chem_269_27819
Edrophonium 1.0 & 0.2 uM - - 50mM NaPhosphate pH8 Acetylthiocholine Kronman_1994_J.Biol.Chem_269_27819

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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