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Kinetic parameters for mutation E389Q/D390N_human-ACHE
Substrate
Molecule
Km
Kcat
Exp. conditions
Reference
3,3-dimethylbutylthioacetate
240 & 40 uM
40000 & 5000/min
IS 5mM
Shafferman_1994_EMBO.J_13_3448
Acetylthiocholine
70 & 10 uM
350000 & 50000/min
IS 5mM
Shafferman_1994_EMBO.J_13_3448
Inhibitor
Molecule
Ki
Ksi
Ic50
Exp. conditions
Substrate
Reference
Edrophonium
0.70 & 0.11 uM
-
-
IS 150 mM
Acetylthiocholine
Shafferman_1994_EMBO.J_13_3448
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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