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Kinetic parameters for mutation F295L_mouse-ACHE
Substrate
Molecule
Km
Kcat
Exp. conditions
Reference
Acetylthiocholine
52 uM
44000 /min
100mM NaPhosphate Ph7.0 T22C
Hosea_1995_Biochemistry_34_11528
Acetylthiocholine
49 & 4 uM
44000 & 7000/min
100mM NaP pH7 T22C eq3 sch3
Radic_1993_Biochemistry_32_12074
Benzoylthiocholine
10 uM
240 /min
100mM NaPhosphate Ph7.0 T22C
Hosea_1995_Biochemistry_34_11528
Butyrylthiocholine
10 uM
12000 /min
100mM NaPhosphate Ph7.0 T22C
Hosea_1995_Biochemistry_34_11528
Inhibitor
Molecule
Ki
Ksi
Ic50
Exp. conditions
Substrate
Reference
WT-fasciculin2
-
7.4 pM
-
100mM NaP pH7.0 T37C eq4 sch4 meth5
Acetylthiocholine
Radic_1994_J.Biol.Chem_269_11233
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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