Gene Locus : human-LIPC
Mode of mutation : Natural mutant
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : No kinetic parameter
News : No news
Comment : The C-->T(-514) allele is associated with lower HL -514C\/T
| Title : The -250G\/A and -514C\/T Polymorphisms in Hepatic Lipase Gene Promoter Confers an Increased Risk of Hepatocellular Carcinoma in a Chinese Population - Niu_2018_Ann.Hepatol_17_992 |
| Author(s) : Niu CZ , Zhang FH , Li Y , Liu JJ , Bao CX |
| Ref : Ann Hepatol , 17 :992 , 2018 |
| Abstract : Niu_2018_Ann.Hepatol_17_992 |
| ESTHER : Niu_2018_Ann.Hepatol_17_992 |
| PubMedSearch : Niu_2018_Ann.Hepatol_17_992 |
| PubMedID: 30600300 |
| Gene_locus related to this paper: human-LIPC |
| Title : Severe hypertriglyceridemia in Japan: Differences in causes and therapeutic responses - Murase_2017_J.Clin.Lipidol_11_1383 |
| Author(s) : Murase T , Okubo M , Ebara T , Mori Y |
| Ref : J Clin Lipidol , 11 :1383 , 2017 |
| Abstract : Murase_2017_J.Clin.Lipidol_11_1383 |
| ESTHER : Murase_2017_J.Clin.Lipidol_11_1383 |
| PubMedSearch : Murase_2017_J.Clin.Lipidol_11_1383 |
| PubMedID: 28958672 |
| Gene_locus related to this paper: human-LPL |
| Title : Wolman's disease and cholesteryl ester storage disorder: the phenotypic spectrum of lysosomal acid lipase deficiency - Pericleous_2017_Lancet.Gastroenterol.Hepatol_2_670 |
| Author(s) : Pericleous M , Kelly C , Wang T , Livingstone C , Ala A |
| Ref : Lancet Gastroenterol Hepatol , 2 :670 , 2017 |
| Abstract : Pericleous_2017_Lancet.Gastroenterol.Hepatol_2_670 |
| ESTHER : Pericleous_2017_Lancet.Gastroenterol.Hepatol_2_670 |
| PubMedSearch : Pericleous_2017_Lancet.Gastroenterol.Hepatol_2_670 |
| PubMedID: 28786388 |
| Title : The -514C\/T Polymorphism of Hepatic Lipase Gene among Iranian Patients with Coronary Heart Disease - Ghatreh_2012_Iran.J.Public.Health_41_59 |
| Author(s) : Ghatreh Samani K , Noori M , Nobar MR , Chaleshtory MH , Farrokhi E , Amin MD |
| Ref : Iran J Public Health , 41 :59 , 2012 |
| Abstract : Ghatreh_2012_Iran.J.Public.Health_41_59 |
| ESTHER : Ghatreh_2012_Iran.J.Public.Health_41_59 |
| PubMedSearch : Ghatreh_2012_Iran.J.Public.Health_41_59 |
| PubMedID: 23113123 |
| Gene_locus related to this paper: human-LIPC |
| Title : Combined hepatic lipase -514C\/T and cholesteryl ester transfer protein I405V polymorphisms are associated with the risk of coronary artery disease - Ghatrehsamani_2009_Genet.Test.Mol.Biomarkers_13_809 |
| Author(s) : Ghatrehsamani K , Darabi M , Rahbani M , Hashemzadeh Chaleshtory M , Farrokhi E , Noori M |
| Ref : Genet Test Mol Biomarkers , 13 :809 , 2009 |
| Abstract : Ghatrehsamani_2009_Genet.Test.Mol.Biomarkers_13_809 |
| ESTHER : Ghatrehsamani_2009_Genet.Test.Mol.Biomarkers_13_809 |
| PubMedSearch : Ghatrehsamani_2009_Genet.Test.Mol.Biomarkers_13_809 |
| PubMedID: 19810818 |
| Gene_locus related to this paper: human-LIPC |
| Title : [Association of hepatic lipase gene promoter polymorphism -514C\/T with nonalcoholic fatty liver disease] - Zhan_2008_Zhonghua.Gan.Zang.Bing.Za.Zhi_16_375 |
| Author(s) : Zhan Q , Li YY , Nie YQ , Zhou YJ , Du YL , Sha WH , Wang H |
| Ref : Zhonghua Gan Zang Bing Za Zhi , 16 :375 , 2008 |
| Abstract : Zhan_2008_Zhonghua.Gan.Zang.Bing.Za.Zhi_16_375 |
| ESTHER : Zhan_2008_Zhonghua.Gan.Zang.Bing.Za.Zhi_16_375 |
| PubMedSearch : Zhan_2008_Zhonghua.Gan.Zang.Bing.Za.Zhi_16_375 |
| PubMedID: 18510853 |
| Gene_locus related to this paper: human-LIPC |
| Title : Hepatic lipase gene -514C\/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations - Wu_2008_Lipids_43_733 |
| Author(s) : Wu J , Yin R , Lin W , Pan S , Yang D |
| Ref : Lipids , 43 :733 , 2008 |
| Abstract : Wu_2008_Lipids_43_733 |
| ESTHER : Wu_2008_Lipids_43_733 |
| PubMedSearch : Wu_2008_Lipids_43_733 |
| PubMedID: 18592285 |
| Gene_locus related to this paper: human-LIPC |
| Title : Hepatic lipase C-514T polymorphism and its association with high-density lipoprotein cholesterol level in Tehran - Daneshpour_2006_Eur.J.Cardiovasc.Prev.Rehabil_13_101 |
| Author(s) : Daneshpour MS , Hedayati M , Azizi F |
| Ref : Eur J Cardiovasc Prev Rehabil , 13 :101 , 2006 |
| Abstract : Daneshpour_2006_Eur.J.Cardiovasc.Prev.Rehabil_13_101 |
| ESTHER : Daneshpour_2006_Eur.J.Cardiovasc.Prev.Rehabil_13_101 |
| PubMedSearch : Daneshpour_2006_Eur.J.Cardiovasc.Prev.Rehabil_13_101 |
| PubMedID: 16449872 |
| Title : Common hepatic lipase gene promoter variant predicts the degree of neointima formation after carotid endarterectomy: impact of plaque composition and lipoprotein phenotype - Zambon_2006_Atherosclerosis_185_121 |
| Author(s) : Zambon A , Puato M , Faggin E , Bertocco S , Vitturi N , Polentarutti V , Deriu GP , Grego F , Bertipaglia B , Rattazzi M , Vianello D , Deeb SS , Pauletto P |
| Ref : Atherosclerosis , 185 :121 , 2006 |
| Abstract : Zambon_2006_Atherosclerosis_185_121 |
| ESTHER : Zambon_2006_Atherosclerosis_185_121 |
| PubMedSearch : Zambon_2006_Atherosclerosis_185_121 |
| PubMedID: 16005462 |
| Title : The -514 C\/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population - Gomez_2005_J.Mol.Endocrinol_34_331 |
| Author(s) : Gomez P , Perez-Jimenez F , Marin C , Moreno JA , Gomez MJ , Bellido C , Perez-Martinez P , Fuentes F , Paniagua JA , Lopez-Miranda J |
| Ref : J Mol Endocrinol , 34 :331 , 2005 |
| Abstract : Gomez_2005_J.Mol.Endocrinol_34_331 |
| ESTHER : Gomez_2005_J.Mol.Endocrinol_34_331 |
| PubMedSearch : Gomez_2005_J.Mol.Endocrinol_34_331 |
| PubMedID: 15821100 |
| Title : Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene - Stefan_2005_J.Clin.Endocrinol.Metab_90_4238 |
| Author(s) : Stefan N , Schafer S , Machicao F , Machann J , Schick F , Claussen CD , Stumvoll M , Haring HU , Fritsche A |
| Ref : J Clinical Endocrinology Metab , 90 :4238 , 2005 |
| Abstract : Stefan_2005_J.Clin.Endocrinol.Metab_90_4238 |
| ESTHER : Stefan_2005_J.Clin.Endocrinol.Metab_90_4238 |
| PubMedSearch : Stefan_2005_J.Clin.Endocrinol.Metab_90_4238 |
| PubMedID: 15855254 |
| Title : Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000 - Arai_2005_J.Atheroscler.Thromb_12_240 |
| Author(s) : Arai H , Yamamoto A , Matsuzawa Y , Saito Y , Yamada N , Oikawa S , Mabuchi H , Teramoto T , Sasaki J , Nakaya N , Itakura H , Ishikawa Y , Ouchi Y , Horibe H , Egashira T , Hattori H , Shirahashi N , Kita T |
| Ref : J Atheroscler Thromb , 12 :240 , 2005 |
| Abstract : Arai_2005_J.Atheroscler.Thromb_12_240 |
| ESTHER : Arai_2005_J.Atheroscler.Thromb_12_240 |
| PubMedSearch : Arai_2005_J.Atheroscler.Thromb_12_240 |
| PubMedID: 16205020 |
| Title : C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects - Yabu_2005_Int.J.Mol.Med_16_421 |
| Author(s) : Yabu Y , Noma K , Nakatani K , Nishioka J , Suematsu M , Katsuki A , Hori Y , Yano Y , Sumida Y , Wada H , Nobori T |
| Ref : Int J Mol Med , 16 :421 , 2005 |
| Abstract : Yabu_2005_Int.J.Mol.Med_16_421 |
| ESTHER : Yabu_2005_Int.J.Mol.Med_16_421 |
| PubMedSearch : Yabu_2005_Int.J.Mol.Med_16_421 |
| PubMedID: 16077949 |
| Title : Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study - Teran-Garcia_2005_Diabetes_54_2251 |
| Author(s) : Teran-Garcia M , Santoro N , Rankinen T , Bergeron J , Rice T , Leon AS , Rao DC , Skinner JS , Bergman RN , Despres JP , Bouchard C |
| Ref : Diabetes , 54 :2251 , 2005 |
| Abstract : Teran-Garcia_2005_Diabetes_54_2251 |
| ESTHER : Teran-Garcia_2005_Diabetes_54_2251 |
| PubMedSearch : Teran-Garcia_2005_Diabetes_54_2251 |
| PubMedID: 15983229 |
| Title : The -514C\/T polymorphism of the hepatic lipase gene significantly modulates the HDL-cholesterol response to statin treatment - Lahoz_2005_Atherosclerosis_182_129 |
| Author(s) : Lahoz C , Pena R , Mostaza JM , Laguna F , Garcia-Iglesias MF , Taboada M , Pinto X |
| Ref : Atherosclerosis , 182 :129 , 2005 |
| Abstract : Lahoz_2005_Atherosclerosis_182_129 |
| ESTHER : Lahoz_2005_Atherosclerosis_182_129 |
| PubMedSearch : Lahoz_2005_Atherosclerosis_182_129 |
| PubMedID: 16115483 |
| Gene_locus related to this paper: human-LIPC |
| Title : Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men - Waterworth_2005_Biochim.Biophys.Acta_1740_375 |
| Author(s) : Waterworth DM , Jansen H , Nicaud V , Humphries SE , Talmud PJ |
| Ref : Biochimica & Biophysica Acta , 1740 :375 , 2005 |
| Abstract : Waterworth_2005_Biochim.Biophys.Acta_1740_375 |
| ESTHER : Waterworth_2005_Biochim.Biophys.Acta_1740_375 |
| PubMedSearch : Waterworth_2005_Biochim.Biophys.Acta_1740_375 |
| PubMedID: 15949705 |
| Title : Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients - Baum_2005_Diabetes.Care_28_1704 |
| Author(s) : Baum L , Ng MC , So WY , Lam VK , Wang Y , Poon E , Tomlinson B , Cheng S , Lindpaintner K , Chan JC |
| Ref : Diabetes Care , 28 :1704 , 2005 |
| Abstract : Baum_2005_Diabetes.Care_28_1704 |
| ESTHER : Baum_2005_Diabetes.Care_28_1704 |
| PubMedSearch : Baum_2005_Diabetes.Care_28_1704 |
| PubMedID: 15983323 |
| Title : Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men - Zhang_2005_Am.J.Clin.Nutr_81_1429 |
| Author(s) : Zhang C , Lopez-Ridaura R , Rimm EB , Rifai N , Hunter DJ , Hu FB |
| Ref : Am J Clin Nutr , 81 :1429 , 2005 |
| Abstract : Zhang_2005_Am.J.Clin.Nutr_81_1429 |
| ESTHER : Zhang_2005_Am.J.Clin.Nutr_81_1429 |
| PubMedSearch : Zhang_2005_Am.J.Clin.Nutr_81_1429 |
| PubMedID: 15941898 |
| Title : Influence of the -514C\/T polymorphism in the promoter of the hepatic lipase gene on postprandial lipoprotein metabolism - Gomez_2004_Atherosclerosis_174_73 |
| Author(s) : Gomez P , Miranda JL , Marin C , Bellido C , Moreno JA , Moreno R , Perez-Martinez P , Perez-Jimenez F |
| Ref : Atherosclerosis , 174 :73 , 2004 |
| Abstract : Gomez_2004_Atherosclerosis_174_73 |
| ESTHER : Gomez_2004_Atherosclerosis_174_73 |
| PubMedSearch : Gomez_2004_Atherosclerosis_174_73 |
| PubMedID: 15135253 |
| Title : The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis - Isaacs_2004_J.Clin.Endocrinol.Metab_89_3858 |
| Author(s) : Isaacs A , Sayed-Tabatabaei FA , Njajou OT , Witteman JC , van Duijn CM |
| Ref : J Clinical Endocrinology Metab , 89 :3858 , 2004 |
| Abstract : Isaacs_2004_J.Clin.Endocrinol.Metab_89_3858 |
| ESTHER : Isaacs_2004_J.Clin.Endocrinol.Metab_89_3858 |
| PubMedSearch : Isaacs_2004_J.Clin.Endocrinol.Metab_89_3858 |
| PubMedID: 15292318 |
| Title : Association of the -514C-->T polymorphism in the hepatic lipase gene (LIPC) promoter with elevated fasting insulin concentrations, but not insulin resistance, in non-diabetic Germans - Machicao_2004_Horm.Metab.Res_36_303 |
| Author(s) : Machicao F , Staiger H , Fritsche A , Guirguis A , Weisser M , Stumvoll M , Haring HU |
| Ref : Hormone & Metabolic Research , 36 :303 , 2004 |
| Abstract : Machicao_2004_Horm.Metab.Res_36_303 |
| ESTHER : Machicao_2004_Horm.Metab.Res_36_303 |
| PubMedSearch : Machicao_2004_Horm.Metab.Res_36_303 |
| PubMedID: 15156410 |
| Title : Hepatic lipase promoter C-514T polymorphism influences serial changes in HDL cholesterol levels since childhood: the Bogalusa Heart Study - Chen_2003_Atherosclerosis_169_175 |
| Author(s) : Chen W , Srinivasan SR , Boerwinkle E , Berenson GS |
| Ref : Atherosclerosis , 169 :175 , 2003 |
| Abstract : Chen_2003_Atherosclerosis_169_175 |
| ESTHER : Chen_2003_Atherosclerosis_169_175 |
| PubMedSearch : Chen_2003_Atherosclerosis_169_175 |
| PubMedID: 12860265 |
| Title : Interaction effect of Serine447Stop variant of the lipoprotein lipase gene and C-514T variant of the hepatic lipase gene on serum triglyceride levels in young adults: the Bogalusa Heart Study - Xin_2003_Metabolism_52_1337 |
| Author(s) : Xin X , Srinivasan SR , Chen W , Boerwinkle E , Berenson GS |
| Ref : Metabolism , 52 :1337 , 2003 |
| Abstract : Xin_2003_Metabolism_52_1337 |
| ESTHER : Xin_2003_Metabolism_52_1337 |
| PubMedSearch : Xin_2003_Metabolism_52_1337 |
| PubMedID: 14564687 |
| Title : Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant - Berk_2003_Diabetes.Care_26_427 |
| Author(s) : Berk P, II , Hoogerbrugge N , Stolk RP , Bootsma AH , Jansen H |
| Ref : Diabetes Care , 26 :427 , 2003 |
| Abstract : Berk_2003_Diabetes.Care_26_427 |
| ESTHER : Berk_2003_Diabetes.Care_26_427 |
| PubMedSearch : Berk_2003_Diabetes.Care_26_427 |
| PubMedID: 12547874 |
| Title : Hepatic lipase C514T polymorphism and its relationship with plasma HDL-C levels and coronary artery disease in Koreans - Park_2003_J.Biochem.Mol.Biol_36_237 |
| Author(s) : Park KW , Choi JH , Chae IH , Cho HJ , Oh S , Kim HS , Lee MM , Park YB , Choi YS |
| Ref : J Biochem Mol Biol , 36 :237 , 2003 |
| Abstract : Park_2003_J.Biochem.Mol.Biol_36_237 |
| ESTHER : Park_2003_J.Biochem.Mol.Biol_36_237 |
| PubMedSearch : Park_2003_J.Biochem.Mol.Biol_36_237 |
| PubMedID: 12689525 |
| Title : Hepatic lipase gene -514 C\/T polymorphism and premature coronary heart disease - Ji_2002_J.Cardiovasc.Risk_9_105 |
| Author(s) : Ji J , Herbison CE , Mamotte CD , Burke V , Taylor RR , van Bockxmeer FM |
| Ref : J Cardiovasc Risk , 9 :105 , 2002 |
| Abstract : Ji_2002_J.Cardiovasc.Risk_9_105 |
| ESTHER : Ji_2002_J.Cardiovasc.Risk_9_105 |
| PubMedSearch : Ji_2002_J.Cardiovasc.Risk_9_105 |
| PubMedID: 12006918 |
| Title : Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study - Ordovas_2002_Circulation_106_2315 |
| Author(s) : Ordovas JM , Corella D , Demissie S , Cupples LA , Couture P , Coltell O , Wilson PW , Schaefer EJ , Tucker KL |
| Ref : Circulation , 106 :2315 , 2002 |
| Abstract : Ordovas_2002_Circulation_106_2315 |
| ESTHER : Ordovas_2002_Circulation_106_2315 |
| PubMedSearch : Ordovas_2002_Circulation_106_2315 |
| PubMedID: 12403660 |
| Title : Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women - Carr_2002_Arterioscler.Thromb.Vasc.Biol_22_667 |
| Author(s) : Carr MC , Ayyobi AF , Murdoch SJ , Deeb SS , Brunzell JD |
| Ref : Arterioscler Thromb Vasc Biol , 22 :667 , 2002 |
| Abstract : Carr_2002_Arterioscler.Thromb.Vasc.Biol_22_667 |
| ESTHER : Carr_2002_Arterioscler.Thromb.Vasc.Biol_22_667 |
| PubMedSearch : Carr_2002_Arterioscler.Thromb.Vasc.Biol_22_667 |
| PubMedID: 11950708 |
| Title : Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men - Talmud_2002_Ann.Hum.Genet_66_111 |
| Author(s) : Talmud PJ , Hawe E , Robertson K , Miller GJ , Miller NE , Humphries SE |
| Ref : Ann Hum Genet , 66 :111 , 2002 |
| Abstract : Talmud_2002_Ann.Hum.Genet_66_111 |
| ESTHER : Talmud_2002_Ann.Hum.Genet_66_111 |
| PubMedSearch : Talmud_2002_Ann.Hum.Genet_66_111 |
| PubMedID: 12174215 |
| Title : Effects of hepatic lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population - Inazu_2001_J.Hum.Genet_46_172 |
| Author(s) : Inazu A , Nishimura Y , Terada Y , Mabuchi H |
| Ref : J Hum Genet , 46 :172 , 2001 |
| Abstract : Inazu_2001_J.Hum.Genet_46_172 |
| ESTHER : Inazu_2001_J.Hum.Genet_46_172 |
| PubMedSearch : Inazu_2001_J.Hum.Genet_46_172 |
| PubMedID: 11322655 |
| Title : Effects of gender, hepatic lipase gene polymorphism and type 2 diabetes mellitus on hepatic lipase activity in Chinese - Tan_2001_Atherosclerosis_157_233 |
| Author(s) : Tan KC , Shiu SW , Chu BY |
| Ref : Atherosclerosis , 157 :233 , 2001 |
| Abstract : Tan_2001_Atherosclerosis_157_233 |
| ESTHER : Tan_2001_Atherosclerosis_157_233 |
| PubMedSearch : Tan_2001_Atherosclerosis_157_233 |
| PubMedID: 11427226 |
| Title : Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study - Couture_2000_Arterioscler.Thromb.Vasc.Biol_20_815 |
| Author(s) : Couture P , Otvos JD , Cupples LA , Lahoz C , Wilson PW , Schaefer EJ , Ordovas JM |
| Ref : Arterioscler Thromb Vasc Biol , 20 :815 , 2000 |
| Abstract : Couture_2000_Arterioscler.Thromb.Vasc.Biol_20_815 |
| ESTHER : Couture_2000_Arterioscler.Thromb.Vasc.Biol_20_815 |
| PubMedSearch : Couture_2000_Arterioscler.Thromb.Vasc.Biol_20_815 |
| PubMedID: 10712408 |
| Title : The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity - Deeb_2000_J.Lipid.Res_41_155 |
| Author(s) : Deeb SS , Peng R |
| Ref : J Lipid Res , 41 :155 , 2000 |
| Abstract : Deeb_2000_J.Lipid.Res_41_155 |
| ESTHER : Deeb_2000_J.Lipid.Res_41_155 |
| PubMedSearch : Deeb_2000_J.Lipid.Res_41_155 |
| PubMedID: 10627514 |