Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Back door hypothesis External charge at the rim of the hypothetical back door,No effect of mutation Shafferman_1992_4th.ChE.Meeting.Eilat__165 Kronman_1994_J.Biol.Chem_269_27819
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Back door hypothesis
Torpedo_number : 128
Kinetic Parameter : 3,3-dimethylbutylthioacetate_D131N_human-ACHE, Acetylthiocholine_D131N_human-ACHE, Edrophonium_D131N_human-ACHE
News : No news
Comment : p.D131N Asp131Asn (p.D152N Asp152Asn in primary sequence with 31 amino-acids signal peptide) Back door hypothesis\;External charge at the rim of the hypothetical back door,No effect of mutation
| Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819 |
| Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :27819 , 1994 |
| Abstract : Kronman_1994_J.Biol.Chem_269_27819 |
| ESTHER : Kronman_1994_J.Biol.Chem_269_27819 |
| PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819 |
| PubMedID: 7961709 |
| Title : Acetylcholinesterase Catalysis - Protein Engineering Studies - |
| Author(s) : Shafferman A , Velan B |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992 |
| PubMedID: |