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Mutation Report for: D188G/E196G/V331A/F390S_boomi-ACHE1

Mode of mutation|Natural mutant
Amino Acid change|D188G/E196G/V331A/F390S
Torpedo number|131//140//275//336//131,140,275,336
Comment|mutation in 336 found in sitav-ACHE1 and 131 in pluxy-ACHE1, likely to be important. The four mutations are present in OP-resistant strain Tuxpan Tx11(R). Other mutations E55G, E60K, P78T, T219A, E238G, A260T, N333S, A349V, T362A, K363R, M426V, T437A, Q488R, I493T, R549H, E552Q, W571F, T576A, N583D where found in strains Deutch5(S), SR4(R,) SR11(R)or Tx11(R) but were present either in both resistant and sensitive strains or unrelated to paraoxon insensitivity
Kinetic parameters|none

    Title: Baculoviral Expression of Presumptive OP-Resistance Mutations in BmAChE1 of Rhipicephalus (Boophilus) microplus (Ixodida: Ixodidae) and Biochemical Resistance to OP Inhibition
    Temeyer KB, Schlechte KG, McDonough WP
    Ref: Journal of Medical Entomology, 56:1318, 2019 : PubMed


    Title: Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi
    Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Perez de Leon AA, Bloomquist JR
    Ref: Pesticide Biochemistry and Physiology, 106:, 2013 : PubMed


    Title: Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus
    Temeyer KB, Pruett JH, Olafson PU
    Ref: Vet Parasitol, 172:114, 2010 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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