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Mutation Report for: D70G/E441G/E443Q_human-BCHE

D70G/E441G/E443Q_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|D70G/E441G/E443Q
Torpedo number|72,443,445//445//443//72
Summary|
Comment|p.D70G/E441G/E443Q Asp70Gly/Glu441Gly/Glu443Gln (p.D98G/E469G/E471Q Asp98Gly/Glu469Gly/Glu4471Gln in primary sequence with 28 amino-acids signal peptide) Succinylcholine hydrolysis/Dibucaine inhibition 441 and 443 bind succinylcholine but mutant do not bind dibucaine
Kinetic parameters|none


References:
    Title: Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE
    Neville LF, Gnatt A, Loewenstein Y, Seidman S, Ehrlich G, Soreq H
    Ref: EMBO Journal, 11:1641, 1992 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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