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Mutation Report for: D70G/S425P_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|D70G/S425P
Torpedo number|72,427//427//72
Comment|p.D70G/S425P Asp70Gly/Ser425Pro (p.D98G/S453P Asp98Gly/Ser453Pro in primary sequence with 28 amino-acids signal peptide) The S425P could be considered as natural but was only found in clones of neuroblastomas and gliostomas, as such are somatic mutations not found in families as abnormal plasma cholinesterases
Kinetic parameters|none

    Title: Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons.
    Schwarz M, Glick D, Loewenstein Y, Soreq H
    Ref: Pharmacol Ther, 67:283, 1995 : PubMed


    Title: Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE
    Neville LF, Gnatt A, Loewenstein Y, Seidman S, Ehrlich G, Soreq H
    Ref: EMBO Journal, 11:1641, 1992 : PubMed


    Title: Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors
    Gnatt A, Prody CA, Zamir R, Lieman-Hurwitz J, Zakut H, Soreq H
    Ref: Cancer Research, 50:1983, 1990 : PubMed


    Title: Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on in-ovo produced human butyrylcholinesterase
    Neville LF, Gnatt A, Loewenstein Y, Soreq H
    Ref: Journal of Neuroscience Research, 27:452, 1990 : PubMed


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