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Mutation Report for: D74N/W286A/Y341A_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|D74N/W286A/Y341A
Torpedo number|72,279,334//279//334//72
Comment|p.D74N/W286A/Y341A Asp74Gln/Trp286Ala/Tyr341Ala (p.D105N/W317A/Y372A Asp105Gln/Trp317Ala/Tyr372Ala in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site;cooperativity of mutations on D74 W286 for bisquaternary PAS inhib
Kinetic parameters|none

    Title: Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases
    Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Leitner M, Segall Y, Bromberg A, Reuveny S and Velan B <4 more author(s)>
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:189, 1995 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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