Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Aging Resistance to penetration of water D70 and E197 function like check valves for water Masson_1999_Chem.Biol.Interact_119-120_17 || Substrate activation moderatly reduced substrate activation Masson_2001_Biochim.Biophys.Acta_1544_166 || Aging E197D increases half-life of aging by DFP 5.8 times Masson_1997_Biochem.J_327_601
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Aging || Substrate activation
Torpedo_number : 199
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.E197D Glu197Asp (p.E225D Glu225Asp in primary sequence with 28 amino-acids signal peptide) moderatly reduced substrate activation\; increases half-life of aging by DFP 5.8 times
| Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166 |
| Author(s) : Masson P , Xie W , Froment MT , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001 |
| Abstract : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| ESTHER : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedID: 11341926 |
| Gene_locus related to this paper: human-BCHE |
| Title : Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process - Masson_1999_Chem.Biol.Interact_119-120_17 |
| Author(s) : Masson P , Fortier PL , Albaret C , Clery C , Guerra P , Lockridge O |
| Ref : Chemico-Biological Interactions , 119-120 :17 , 1999 |
| Abstract : Masson_1999_Chem.Biol.Interact_119-120_17 |
| ESTHER : Masson_1999_Chem.Biol.Interact_119-120_17 |
| PubMedSearch : Masson_1999_Chem.Biol.Interact_119-120_17 |
| PubMedID: 10421435 |
| Title : Aging of di-isopropyl-phosphorylated human butyrylcholinesterase - Masson_1997_Biochem.J_327_601 |
| Author(s) : Masson P , Fortier PL , Albaret C , Froment MT , Bartels CF , Lockridge O |
| Ref : Biochemical Journal , 327 ( Pt 2) :601 , 1997 |
| Abstract : Masson_1997_Biochem.J_327_601 |
| ESTHER : Masson_1997_Biochem.J_327_601 |
| PubMedSearch : Masson_1997_Biochem.J_327_601 |
| PubMedID: 9359435 |