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Mutation Report for: E441G/E443Q_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|E441G/E443G
Torpedo number|443,445//445//443
Comment|p.E441G/E443Q Glu441Gly/Glu443Gln (p.E469G/E471Q Glu469Gly/Glu471Gln in primary sequence with 28 amino-acids signal peptide) drastically reduced activity towards BTC modifies the eletronegativity environment of H438
Kinetic parameters|none

    Title: Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE
    Neville LF, Gnatt A, Loewenstein Y, Seidman S, Ehrlich G, Soreq H
    Ref: EMBO Journal, 11:1641, 1992 : PubMed


    Title: Excavations into the active-site gorge of cholinesterases.
    Soreq H, Gnatt A, Loewenstein Y, Neville LF
    Ref: Trends in Biochemical Sciences, 17:353, 1992 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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