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Mutation Report for: F295A/F297A_human-ACHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|F295A/F297A
Torpedo number|288//290//288,290
Comment|p.F295A/F297A Phe295Ala/Phe297Ala (p.F326A/F328A Phe326Ala/Phe328Ala in primary sequence with 31 amino-acids signal peptide)Acyl specificity;VX stereospecificity decrease in stereoselectivity
Kinetic parameters|none

    Title: The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers
    Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A and Shafferman A <2 more author(s)>
    Ref: Chemico-Biological Interactions, 157-158:191, 2005 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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