Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Oxyanion hole significant reduction of activity Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Oxyanion hole
Torpedo_number : 117
Kinetic Parameter : Butyrylthiocholine_G115E_human-BCHE
News : No news
Comment : p.G115E Gly115Glu (p.G143E Gly143Glu in primary sequence with 28 amino-acids signal peptide) Oxyanion hole\;significant reduction of activity
Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
Ref : Molecular Pharmacology , 50 :1423 , 1996 |
Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
PubMedID: 8967962 |
Gene_locus related to this paper: human-BCHE |