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Mutation Report for: G115H_human-BCHE

G115H_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|G115H
Torpedo number|117
Summary|
Comment|p.G115H Gly115His (p.G143H Gly143His in primary sequence with 28 amino-acids signal peptide) No catalytic activity
Kinetic parameters|none


References:
    Title: A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase
    Lockridge O, Blong RM, Masson P, Froment MT, Millard CB, Broomfield CA
    Ref: Biochemistry, 36:786, 1997 : PubMed

            

    Title: Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 34:15925, 1995 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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