Kinetic parameters

Tree Display

AceDB Schema

XML Display


Mutation Report for: G117H/E197Q_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|G117H/E197Q
Torpedo number|199//119//119,199
Comment|p.G117H/E197Q Gly117His/Glu197Gln (p.G145H/E225Q Gly145His/Glu225Gln in primary sequence with 28 amino-acids signal peptide) Phosphotriesterase activity
Kinetic parameters|none

    Title: Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization
    Broomfield CA, Lockridge O, Millard CB
    Ref: Chemico-Biological Interactions, 119-120:413, 1999 : PubMed


    Title: Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 37:237, 1998 : PubMed


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer