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Mutation Report for: G119S_anoga-ACHE1

Mode of mutation|Natural mutant
Amino Acid change|G119S
Torpedo number|119
Comment|p.Gly119Ser. (G280S in sequence with 38 aa signal peptide and long N-term extra sequence, G122 in human AChE) In Anopheles albimanus individuals resistant to fenitrothion, malathion, and bendiocarb are heterozygous at the first base (G/T) and either heterozygous (G/C) or homozygous mutants (C/C) at the second base. Liebman et al.
Kinetic parameters|none

    Title: Distribution of acetylcholinesterase (Ace-1(R)) target-site G119S mutation and resistance to carbamates and organophosphates in Anopheles gambiae sensu lato populations from Cameroon
    Binyang AJ, Elanga-Ndille E, Tene-Fossog B, Ndo C, Nouage L, Assatse T, Fotso-Toguem Y, Tabue R, Zeukeng F and Wondji CS <3 more author(s)>
    Ref: Parasit Vectors, 15:53, 2022 : PubMed


    Title: Acetylcholinesterase (ace-1(R)) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali
    Keita M, Kane F, Thiero O, Traore B, Zeukeng F, Sodio AB, Traore SF, Djouaka R, Doumbia S, Sogoba N
    Ref: Parasit Vectors, 13:283, 2020 : PubMed


    Title: The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS Implementation
    Elanga-Ndille E, Nouage L, Ndo C, Binyang A, Assatse T, Nguiffo-Nguete D, Djonabaye D, Irwing H, Tene-Fossog B, Wondji CS
    Ref: Genes (Basel), 10:, 2019 : PubMed


    Title: Resistance to pyrethroid and organophosphate insecticides, and the geographical distribution and polymorphisms of target-site mutations in voltage-gated sodium channel and acetylcholinesterase 1 genes in Anopheles sinensis populations in Shanghai, China
    Fang Y, Shi WQ, Wu JT, Li YY, Xue JB, Zhang Y
    Ref: Parasit Vectors, 12:396, 2019 : PubMed


    Title: Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance
    Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR
    Ref: Structure, 26:130, 2018 : PubMed


    Title: Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes
    Engdahl C, Knutsson S, Ekstrom F, Linusson A
    Ref: Journal of Medicinal Chemistry, 59:9409, 2016 : PubMed


    Title: Detection of G119S ace-1 (R) mutation in field-collected Anopheles gambiae mosquitoes using allele-specific loop-mediated isothermal amplification (AS-LAMP) method
    Badolo A, Bando H, Traore A, Ko-Ketsu M, Guelbeogo WM, Kanuka H, Ranson H, Sagnon N, Fukumoto S
    Ref: Malar J, 14:477, 2015 : PubMed


    Title: Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues
    Engdahl C, Knutsson S, Fredriksson SA, Linusson A, Bucht G, Ekstrom F
    Ref: PLoS ONE, 10:e0138598, 2015 : PubMed


    Title: Distribution and frequency of G119S mutation in ace-1 gene within Anopheles sinensis populations from Guangxi, China
    Feng X, Yang C, Yang Y, Li J, Lin K, Li M, Qiu X
    Ref: Malar J, 14:470, 2015 : PubMed


    Title: Novel mutations on the ace-1 gene of the malaria vector Anopheles albimanus provide evidence for balancing selection in an area of high insecticide resistance in Peru
    Liebman KA, Pinto J, Valle J, Palomino M, Vizcaino L, Brogdon W, Lenhart A
    Ref: Malar J, 14:599, 2015 : PubMed


    Title: Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae
    Weetman D, Mitchell SN, Wilding CS, Birks DP, Yawson AE, Essandoh J, Mawejje HD, Djogbenou LS, Steen K and Donnelly MJ <4 more author(s)>
    Ref: Mol Ecol, 24:2656, 2015 : PubMed


    Title: Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallee de Kou, Burkina Faso
    Kwiatkowska RM, Platt N, Poupardin R, Irving H, Dabire RK, Mitchell S, Jones CM, Diabate A, Ranson H, Wondji CS
    Ref: Gene, 519:98, 2013 : PubMed


    Title: Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae
    Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR
    Ref: Chemico-Biological Interactions, 203:314, 2013 : PubMed


    Title: Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase
    Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL and Carlier PR <4 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 22:4593, 2012 : PubMed


    Title: Select small core structure carbamates exhibit high contact toxicity to carbamate-resistant strain malaria mosquitoes, Anopheles gambiae (Akron)
    Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL and Carlier PR <6 more author(s)>
    Ref: PLoS ONE, 7:e46712, 2012 : PubMed


    Title: Insecticide resistance in the Anopheles gambiae complex in Benin: a nationwide survey
    Djogbenou L, Pasteur N, Akogbeto M, Weill M, Chandre F
    Ref: Med Vet Entomol, 25:256, 2011 : PubMed


    Title: Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Cote d'Ivoire
    Ahoua Alou LP, Koffi AA, Adja MA, Tia E, Kouassi PK, Kone M, Chandre F
    Ref: Malar J, 9:167, 2010 : PubMed


    Title: Development of high-throughput real-time PCR assays for the identification of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae
    Bass C, Nikou D, Vontas J, Williamson MS, Field LM
    Ref: Pesticide Biochemistry and Physiology, 96:80, 2010 : PubMed


    Title: Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes
    Alout H, Weill M
    Ref: Chemico-Biological Interactions, 175:138, 2008 : PubMed


    Title: Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae
    Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC and Bloomquist JR <1 more author(s)>
    Ref: Chemico-Biological Interactions, 175:368, 2008 : PubMed


    Title: Evidence of introgression of the ace-1(R) mutation and of the ace-1 duplication in West African Anopheles gambiae s. s
    Djogbenou L, Chandre F, Berthomieu A, Dabire R, Koffi A, Alout H, Weill M
    Ref: PLoS ONE, 3:e2172, 2008 : PubMed


    Title: Characterization of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae (Diptera: Culicidae): resistance levels and dominance
    Djogbenou L, Weill M, Hougard JM, Raymond M, Akogbeto M, Chandre F
    Ref: Journal of Medical Entomology, 44:805, 2007 : PubMed


    Title: The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors
    Weill M, Malcolm C, Chandre F, Mogensen K, Berthomieu A, Marquine M, Raymond M
    Ref: Insect Molecular Biology, 13:1, 2004 : PubMed


    Title: Comparative genomics: Insecticide resistance in mosquito vectors
    Weill M, Lutfalla G, Mogensen K, Chandre F, Berthomieu A, Berticat C, Pasteur N, Philips A, Fort P, Raymond M
    Ref: Nature, 423:136, 2003 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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