Gene Locus : culpi-ACHE1
Mode of mutation : Natural mutant
Disease :
Summary : OP-resistance Mutant are resistant to OP insecticides, This mutation occurred twice in the C. pipiens complex and once in A. Gambiae Weill_2003_Nature_423_136 || OP-resistance G119S substitution in resistant C. vishnui mosquitoes in china Alout_2007_J.Med.Entomol_44_463 || OP-resistance G247S substitution in resistant mosquitoes in china Zhao_2014_PLoS.One_9_e952607 || OP-resistance malathion resistance in Culex quinquefasciatus Say populations in Malaysia Low_2013_Pest.Manag.Sci_69_1362 || OP-resistance resistance in Culex pipiens field populations from north-eastern areas of Italy Toma_2011_Pest.Manag.Sci_67_100
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 119
Kinetic Parameter : No kinetic parameter
News : JUNE-08-2007, MAY-13-2003
Comment : G247S in Zhao et al. GenBank under the accession number KF680946 || p.Gly119Ser
| Title : Evolutionary trade-offs associated with copy number variations in resistance alleles in Culex pipiens mosquitoes - Milesi_2022_Parasit.Vectors_15_484 |
| Author(s) : Milesi P , Claret JL , Unal S , Weill M , Labbe P |
| Ref : Parasit Vectors , 15 :484 , 2022 |
| Abstract : Milesi_2022_Parasit.Vectors_15_484 |
| ESTHER : Milesi_2022_Parasit.Vectors_15_484 |
| PubMedSearch : Milesi_2022_Parasit.Vectors_15_484 |
| PubMedID: 36550589 |
| Title : High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaound, Cameroon - Talipouo_2021_Sci.Rep_11_7322 |
| Author(s) : Talipouo A , Mavridis K , Nchoutpouen E , Djiappi-Tchamen B , Fotakis EA , Kopya E , Bamou R , Kekeunou S , Awono-Ambene P , Balabanidou V , Balaska S , Wondji CS , Vontas J , Antonio-Nkondjio C |
| Ref : Sci Rep , 11 :7322 , 2021 |
| Abstract : Talipouo_2021_Sci.Rep_11_7322 |
| ESTHER : Talipouo_2021_Sci.Rep_11_7322 |
| PubMedSearch : Talipouo_2021_Sci.Rep_11_7322 |
| PubMedID: 33795804 |
| Title : Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus - Atyame_2019_Proc.Biol.Sci_286_20182273 |
| Author(s) : Atyame CM , Alout H , Mousson L , Vazeille M , Diallo M , Weill M , Failloux AB |
| Ref : Proc Biol Sci , 286 :20182273 , 2019 |
| Abstract : Atyame_2019_Proc.Biol.Sci_286_20182273 |
| ESTHER : Atyame_2019_Proc.Biol.Sci_286_20182273 |
| PubMedSearch : Atyame_2019_Proc.Biol.Sci_286_20182273 |
| PubMedID: 30963855 |
| Title : G119S ace-1 mutation conferring insecticide resistance detected in the Culex pipiens complex in Morocco - Bkhache_2019_Pest.Manag.Sci_75_286 |
| Author(s) : Bkhache M , Tmimi FZ , Charafeddine O , Filali OB , Lemrani M , Labbe P , Sarih M |
| Ref : Pest Manag Sci , 75 :286 , 2019 |
| Abstract : Bkhache_2019_Pest.Manag.Sci_75_286 |
| ESTHER : Bkhache_2019_Pest.Manag.Sci_75_286 |
| PubMedSearch : Bkhache_2019_Pest.Manag.Sci_75_286 |
| PubMedID: 29885052 |
| Title : Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus - Silva_2019_Sci.Rep_9_11406 |
| Author(s) : Silva Martins WF , Wilding CS , Isaacs AT , Rippon EJ , Megy K , Donnelly MJ |
| Ref : Sci Rep , 9 :11406 , 2019 |
| Abstract : Silva_2019_Sci.Rep_9_11406 |
| ESTHER : Silva_2019_Sci.Rep_9_11406 |
| PubMedSearch : Silva_2019_Sci.Rep_9_11406 |
| PubMedID: 31388075 |
| Title : Entomological status of Anopheles sergentii and the first molecular investigation of its insecticide-resistant genes, kdr and ace-1 in Morocco - Filali_2019_J.Vector.Borne.Dis_56_308 |
| Author(s) : Filali OB , Faraj C , Kabine M , Debboun M , Sarih M |
| Ref : J Vector Borne Dis , 56 :308 , 2019 |
| Abstract : Filali_2019_J.Vector.Borne.Dis_56_308 |
| ESTHER : Filali_2019_J.Vector.Borne.Dis_56_308 |
| PubMedSearch : Filali_2019_J.Vector.Borne.Dis_56_308 |
| PubMedID: 33269730 |
| Title : Insecticide resistance and target site mutations (G119S ace-1 and L1014F kdr) of Culex pipiens in Morocco - Tmimi_2018_Parasit.Vectors_11_51 |
| Author(s) : Tmimi FZ , Faraj C , Bkhache M , Mounaji K , Failloux AB , Sarih M |
| Ref : Parasit Vectors , 11 :51 , 2018 |
| Abstract : Tmimi_2018_Parasit.Vectors_11_51 |
| ESTHER : Tmimi_2018_Parasit.Vectors_11_51 |
| PubMedSearch : Tmimi_2018_Parasit.Vectors_11_51 |
| PubMedID: 29357900 |
| Title : Multiple insecticide resistance in Culex quinquefasciatus populations from Guadeloupe (French West Indies) and associated mechanisms - Delannay_2018_PLoS.One_13_e0199615 |
| Author(s) : Delannay C , Goindin D , Kellaou K , Ramdini C , Gustave J , Vega-Rua A |
| Ref : PLoS ONE , 13 :e0199615 , 2018 |
| Abstract : Delannay_2018_PLoS.One_13_e0199615 |
| ESTHER : Delannay_2018_PLoS.One_13_e0199615 |
| PubMedSearch : Delannay_2018_PLoS.One_13_e0199615 |
| PubMedID: 29944713 |
| Title : Malathion Resistance Status and Mutations in Acetylcholinesterase Gene (Ace) in Japanese Encephalitis and Filariasis Vectors from Endemic Area in India - Misra_2015_J.Med.Entomol_52_442 |
| Author(s) : Misra BR , Gore M |
| Ref : Journal of Medical Entomology , 52 :442 , 2015 |
| Abstract : Misra_2015_J.Med.Entomol_52_442 |
| ESTHER : Misra_2015_J.Med.Entomol_52_442 |
| PubMedSearch : Misra_2015_J.Med.Entomol_52_442 |
| PubMedID: 26334819 |
| Title : Point Mutations Associated with Organophosphate and Carbamate Resistance in Chinese Strains of Culex pipiens quinquefasciatus (Diptera: Culicidae) - Zhao_2014_PLoS.One_9_e952607 |
| Author(s) : Zhao M , Dong Y , Ran X , Wu Z , Guo X , Zhang Y , Xing D , Yan T , Wang G , Zhu X , Zhang H , Li C , Zhao T |
| Ref : PLoS ONE , 9 :e95260 , 2014 |
| Abstract : Zhao_2014_PLoS.One_9_e952607 |
| ESTHER : Zhao_2014_PLoS.One_9_e952607 |
| PubMedSearch : Zhao_2014_PLoS.One_9_e952607 |
| PubMedID: 24788312 |
| Gene_locus related to this paper: culpi-ACHE1 |
| Title : GENE-dosage effects on fitness in recent adaptive duplications: ace-1 in the mosquito Culex pipiens - Labbe_2014_Evolution_68_2092 |
| Author(s) : Labbe P , Milesi P , Yebakima A , Pasteur N , Weill M , Lenormand T |
| Ref : Evolution , 68 :2092 , 2014 |
| Abstract : Labbe_2014_Evolution_68_2092 |
| ESTHER : Labbe_2014_Evolution_68_2092 |
| PubMedSearch : Labbe_2014_Evolution_68_2092 |
| PubMedID: 24494966 |
| Title : First molecular genotyping of insensitive acetylcholinesterase associated with malathion resistance in Culex quinquefasciatus Say populations in Malaysia - Low_2013_Pest.Manag.Sci_69_1362 |
| Author(s) : Low VL , Chen CD , Lim PE , Lee HL , Lim YA , Tan TK , Sofian-Azirun M |
| Ref : Pest Manag Sci , 69 :1362 , 2013 |
| Abstract : Low_2013_Pest.Manag.Sci_69_1362 |
| ESTHER : Low_2013_Pest.Manag.Sci_69_1362 |
| PubMedSearch : Low_2013_Pest.Manag.Sci_69_1362 |
| PubMedID: 23404830 |
| Gene_locus related to this paper: culpi-ACHE1 |
| Title : Multiple Insecticide Resistances in the Disease Vector Culex p. Quinquefasciatus from Western Indian Ocean - Pocquet_2013_PLoS.One_8_e77855 |
| Author(s) : Pocquet N , Milesi P , Makoundou P , Unal S , Zumbo B , Atyame C , Darriet F , Dehecq JS , Thiria J , Bheecarry A , Iyaloo DP , Weill M , Chandre F , Labbe P |
| Ref : PLoS ONE , 8 :e77855 , 2013 |
| Abstract : Pocquet_2013_PLoS.One_8_e77855 |
| ESTHER : Pocquet_2013_PLoS.One_8_e77855 |
| PubMedSearch : Pocquet_2013_PLoS.One_8_e77855 |
| PubMedID: 24204997 |
| Title : Insecticide resistance to organophosphates in Culex pipiens complex from Lebanon - Osta_2012_Parasit.Vectors_5_132 |
| Author(s) : Osta MA , Rizk ZJ , Labbe P , Weill M , Knio K |
| Ref : Parasit Vectors , 5 :132 , 2012 |
| Abstract : Osta_2012_Parasit.Vectors_5_132 |
| ESTHER : Osta_2012_Parasit.Vectors_5_132 |
| PubMedSearch : Osta_2012_Parasit.Vectors_5_132 |
| PubMedID: 22759898 |
| Gene_locus related to this paper: culpi-ACHE1 |
| Title : Comparison of biochemical and molecular tests for detecting insecticide resistance due to insensitive acetylcholinesterase in Culex quinquefasciatus - Scott_2012_J.Am.Mosq.Control.Assoc_28_323 |
| Author(s) : Scott ML , McAllister JC |
| Ref : J Am Mosq Control Assoc , 28 :323 , 2012 |
| Abstract : Scott_2012_J.Am.Mosq.Control.Assoc_28_323 |
| ESTHER : Scott_2012_J.Am.Mosq.Control.Assoc_28_323 |
| PubMedSearch : Scott_2012_J.Am.Mosq.Control.Assoc_28_323 |
| PubMedID: 23393758 |
| Title : Status of insecticide resistance in Culex pipiens field populations from north-eastern areas of Italy before the withdrawal of OP compounds - Toma_2011_Pest.Manag.Sci_67_100 |
| Author(s) : Toma L , Menegon M , Romi R , De Matthaeis E , Montanari M , Severini C |
| Ref : Pest Manag Sci , 67 :100 , 2011 |
| Abstract : Toma_2011_Pest.Manag.Sci_67_100 |
| ESTHER : Toma_2011_Pest.Manag.Sci_67_100 |
| PubMedSearch : Toma_2011_Pest.Manag.Sci_67_100 |
| PubMedID: 21162149 |
| Title : High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria - Alout_2011_Insect.Biochem.Mol.Biol_41_29 |
| Author(s) : Alout H , Labbe P , Pasteur N , Weill M |
| Ref : Insect Biochemistry & Molecular Biology , 41 :29 , 2011 |
| Abstract : Alout_2011_Insect.Biochem.Mol.Biol_41_29 |
| ESTHER : Alout_2011_Insect.Biochem.Mol.Biol_41_29 |
| PubMedSearch : Alout_2011_Insect.Biochem.Mol.Biol_41_29 |
| PubMedID: 20887788 |
| Title : Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations - Alout_2009_Insect.Biochem.Mol.Biol_39_884 |
| Author(s) : Alout H , Labbe P , Berthomieu A , Pasteur N , Weill M |
| Ref : Insect Biochemistry & Molecular Biology , 39 :884 , 2009 |
| Abstract : Alout_2009_Insect.Biochem.Mol.Biol_39_884 |
| ESTHER : Alout_2009_Insect.Biochem.Mol.Biol_39_884 |
| PubMedSearch : Alout_2009_Insect.Biochem.Mol.Biol_39_884 |
| PubMedID: 19874892 |
| Title : Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes - Alout_2008_Chem.Biol.Interact_175_138 |
| Author(s) : Alout H , Weill M |
| Ref : Chemico-Biological Interactions , 175 :138 , 2008 |
| Abstract : Alout_2008_Chem.Biol.Interact_175_138 |
| ESTHER : Alout_2008_Chem.Biol.Interact_175_138 |
| PubMedSearch : Alout_2008_Chem.Biol.Interact_175_138 |
| PubMedID: 18468592 |
| Title : Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China - Alout_2007_J.Med.Entomol_44_463 |
| Author(s) : Alout H , Berthomieu A , Cui F , Tan Y , Berticat C , Qiao C , Weill M |
| Ref : Journal of Medical Entomology , 44 :463 , 2007 |
| Abstract : Alout_2007_J.Med.Entomol_44_463 |
| ESTHER : Alout_2007_J.Med.Entomol_44_463 |
| PubMedSearch : Alout_2007_J.Med.Entomol_44_463 |
| PubMedID: 17547232 |
| Gene_locus related to this paper: culpi-ACHE1 |
| Title : Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae) - Cui_2006_J.Med.Entomol_43_878 |
| Author(s) : Cui F , Raymond M , Berthomieu A , Alout H , Weill M , Qiao CL |
| Ref : Journal of Medical Entomology , 43 :878 , 2006 |
| Abstract : Cui_2006_J.Med.Entomol_43_878 |
| ESTHER : Cui_2006_J.Med.Entomol_43_878 |
| PubMedSearch : Cui_2006_J.Med.Entomol_43_878 |
| PubMedID: 17017223 |
| Gene_locus related to this paper: culpi-ACHE1 |
| Title : The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors - Weill_2004_Insect.Mol.Biol_13_1 |
| Author(s) : Weill M , Malcolm C , Chandre F , Mogensen K , Berthomieu A , Marquine M , Raymond M |
| Ref : Insect Molecular Biology , 13 :1 , 2004 |
| Abstract : Weill_2004_Insect.Mol.Biol_13_1 |
| ESTHER : Weill_2004_Insect.Mol.Biol_13_1 |
| PubMedSearch : Weill_2004_Insect.Mol.Biol_13_1 |
| PubMedID: 14728661 |
| Gene_locus related to this paper: anoga-ACHE1 , culpi-ACHE1 |
| Title : Comparative genomics: Insecticide resistance in mosquito vectors - Weill_2003_Nature_423_136 |
| Author(s) : Weill M , Lutfalla G , Mogensen K , Chandre F , Berthomieu A , Berticat C , Pasteur N , Philips A , Fort P , Raymond M |
| Ref : Nature , 423 :136 , 2003 |
| Abstract : Weill_2003_Nature_423_136 |
| ESTHER : Weill_2003_Nature_423_136 |
| PubMedSearch : Weill_2003_Nature_423_136 |
| PubMedID: 12736674 |
| Gene_locus related to this paper: anoga-ACHE1 , culpi-ACHE1 |