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Mutation Report for: I111V_human-BCHE

I111V_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|I111V
Torpedo number|113
Summary|
Comment|p.I111V Ile111Val (p.I139V Ile139Val in primary sequence with 28 amino-acids signal peptide) Mutation designed by -Protein Repair One Stop Shop- process for the production of active human butyrylcholinesterase in a prokaryotic system. The mutation gives Val as in ACHE of Torpedo californica and human but not mouse
Kinetic parameters|none


References:
    Title: Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development
    Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F
    Ref: Molecules, 22:, 2017 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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