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Mutation Report for: I198T_human-PLA2G7

Gene_Locushuman-PLA2G7 Amino Acid change Torpedo number
Mode of mutationNatural mutant
Kinetic parametersnone
Summary
    CommentCommon polymorphism; associated with asthma and atopy. rs1805018
    References
      Title: Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population
      Chi Y, Shi C, Zhang X, Xi Y
      Ref: J Thromb Thrombolysis, 46:125, 2018 : PubMed

              

      Title: Associations between four types of single-nucleotide polymorphisms in PLA2G7 gene and clinical atherosclerosis: a meta-analysis
      Santoso A, Maulana R, Alzahra F, Maghfirah I, Putrinarita AD, Heriansyah T
      Ref: Am J Cardiovasc Dis, 7:122, 2017 : PubMed

              

      Title: Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)
      Hoffmann MM, Winkler K, Renner W, Winkelmann BR, Seelhorst U, Wellnitz B, Boehm BO, Marz W
      Ref: J Thromb Haemost, 7:41, 2009 : PubMed

              

      Title: Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype
      Li S, Stuart L, Zhang Y, Meduri GU, Umberger R, Yates CR
      Ref: J Clin Pharm Ther, 34:447, 2009 : PubMed

              

      Title: Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
      Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, Haynes C, Goldschmidt-Clermont PJ, Vance JM and Hauser ER <3 more author(s)>
      Ref: Hum Mol Genet, 17:1318, 2008 : PubMed

              

      Title: Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension
      Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, Kamide K, Kawano Y, Miyata T
      Ref: Hypertens Res, 29:611, 2006 : PubMed

              

      Title: The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma
      Kruse S, Mao XQ, Heinzmann A, Blattmann S, Roberts MH, Braun S, Gao PS, Forster J, Kuehr J and Deichmann KA <2 more author(s)>
      Ref: American Journal of Human Genetics, 66:1522, 2000 : PubMed

              

      Title: Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia
      Bell R, Collier DA, Rice SQ, Roberts GW, Macphee CH, Kerwin RW, Price J, Gloger IS
      Ref: Biochemical & Biophysical Research Communications, 241:630, 1997 : PubMed

              


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    Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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