Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Acyl specificity Acyl pocket, Km X 4 for BTC Gnatt_1994_J.Neurochem_62_749
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity
Torpedo_number : 288
Kinetic Parameter : Butyrylthiocholine_L286D_human-BCHE, Echothiophate_L286D_human-BCHE, Iso-OMPA_L286D_human-BCHE, DFP_L286D_human-BCHE
News : No news
Comment : p.L286D Leu286Asp(p.L314D Leu314Asp in primary sequence with 28 amino-acids signal peptide) Acyl pocket, Km X 4 for BTC
| Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749 |
| Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H |
| Ref : Journal of Neurochemistry , 62 :749 , 1994 |
| Abstract : Gnatt_1994_J.Neurochem_62_749 |
| ESTHER : Gnatt_1994_J.Neurochem_62_749 |
| PubMedSearch : Gnatt_1994_J.Neurochem_62_749 |
| PubMedID: 8294937 |