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Mutation Report for: N390Y_bemta-ACHE1

N390Y_bemta-ACHE1
Gene_Locus|bemta-ACHE1
Mode of mutation|Site directed mutagenesis
Amino Acid change|N390Y
Torpedo number|329
Summary|
Comment|p.Asn390Tyr N329Y with Torpedo numbering. The artificial substitution of N390 (wild form) to Y (putative ancient form) led to reduced catalytic efficiency and increased inhibition by glycoalkaloids, suggesting that the Y390N substitution in BtAChE1 may have been required for Solanaceae host adaptation
Kinetic parameters|none


References:
    Title: Molecular and kinetic characterization of two acetylcholinesterases with particular focus on the roles of two amino acid substitutions (Y390N and F392W) in Bemisia tabaci
    Kim S, Yoon KA, Cho S, Lee SH
    Ref: Pestic Biochem Physiol, 182:105039, 2022 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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