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Mutation Report for: PYGTP281-284EPYNGTA/G117H_human-BCHE

PYGTP281-284EPYNGTA/G117H_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|
Torpedo number|283//284//285//286//287//119//119,283,284,285,286,287
Summary|
Comment|computer simulation-driven strategy identified a surface peptide loop (residues 278-285) exhibiting dynamic motions during catalysis. The 3 amino acids insertions FVVPYGTP278-285FVVEPYNGTAP induced a slight but significant increase in reactivation of paraoxon inhibited enzyme
Kinetic parameters|none


References:
    Title: Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis
    Hester KP, Bhattarai K, Jiang H, Agarwal PK, Pope C
    Ref: Chemical Research in Toxicology, 32:1801, 2019 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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