Q642-644del_bacol-ACHE

General

Gene Locus : bacol-ACHE

Mode of mutation : Natural mutant

Disease :

Summary : OP-resistance found associated with resistance Kakani_2008_Insect.Biochem.Mol.Biol_38_781 || OP-resistance OP-resistance (omethoate) Kakani_2011_Insect.Biochem.Mol.Biol_41_150

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 551, 553, 554, 551,553,554

Kinetic Parameter : No kinetic parameter

News : No news

Comment : the deletion of 3 Q may improve GPI anchoring thus increasing the amount of AChE that reaches the synaptic cleft || a short deletion of three glutamines Delta3Q from a stretch of five glutamines in the C-terminal peptide that is normally cleaved and substituted by a GPI anchor

References (5)

Title : A Re-Evaluation of Olive Fruit Fly Organophosphate-Resistant Ace Alleles in Iberia, and Field-Testing Population Effects after in-Practice Dimethoate Use - Nobre_2019_Insects_10_
Author(s) : Nobre T , Gomes L , Rei FT
Ref : Insects , 10 : , 2019
Abstract : Nobre_2019_Insects_10_
ESTHER : Nobre_2019_Insects_10_
PubMedSearch : Nobre_2019_Insects_10_
PubMedID: 31374903

Title : Geographical distribution and frequencies of organophosphate-resistant Ace alleles and morphometric variations in olive fruit fly populations - Dogac_2015_Pest.Manag.Sci_71_1529
Author(s) : Dogac E , Kandemir I , Taskin V
Ref : Pest Manag Sci , 71 :1529 , 2015
Abstract : Dogac_2015_Pest.Manag.Sci_71_1529
ESTHER : Dogac_2015_Pest.Manag.Sci_71_1529
PubMedSearch : Dogac_2015_Pest.Manag.Sci_71_1529
PubMedID: 25491602

Title : Frequencies of organophosphate resistance-associated mutations in the acetylcholinesterase gene of field collected olive fly (Bactrocera oleae) populations under different insecticide regimes - Baskurt_2011_Acta.Biol.Hung_62_22
Author(s) : Baskurt SI , Dogac E , Taskin V , Taskin BI
Ref : Acta Biologica Hungarica , 62 :22 , 2011
Abstract : Baskurt_2011_Acta.Biol.Hung_62_22
ESTHER : Baskurt_2011_Acta.Biol.Hung_62_22
PubMedSearch : Baskurt_2011_Acta.Biol.Hung_62_22
PubMedID: 21388916

Title : Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides. - Kakani_2011_Insect.Biochem.Mol.Biol_41_150
Author(s) : Kakani EG , Bon S , Massoulie J , Mathiopoulos KD
Ref : Insect Biochemistry & Molecular Biology , 41 :150 , 2011
Abstract : Kakani_2011_Insect.Biochem.Mol.Biol_41_150
ESTHER : Kakani_2011_Insect.Biochem.Mol.Biol_41_150
PubMedSearch : Kakani_2011_Insect.Biochem.Mol.Biol_41_150
PubMedID: 21112395

Title : A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organophosphate resistance - Kakani_2008_Insect.Biochem.Mol.Biol_38_781
Author(s) : Kakani EG , Ioannides IM , Margaritopoulos JT , Seraphides NA , Skouras PJ , Tsitsipis JA , Mathiopoulos KD
Ref : Insect Biochemistry & Molecular Biology , 38 :781 , 2008
Abstract : Kakani_2008_Insect.Biochem.Mol.Biol_38_781
ESTHER : Kakani_2008_Insect.Biochem.Mol.Biol_38_781
PubMedSearch : Kakani_2008_Insect.Biochem.Mol.Biol_38_781
PubMedID: 18625401