Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site no changes in Kcat Km for esters Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site
Torpedo_number : 122
Kinetic Parameter : Butyrylthiocholine_T120E_human-BCHE, Tacrine_T120E_human-BCHE, Succinylcholine~Suxamethonium_T120E_human-BCHE, Dibucaine_T120E_human-BCHE, Solanine_T120E_human-BCHE, BW284C51_T120E_human-BCHE
News : No news
Comment : p.T120E Thr120Glu (p.T148E Thr148Glu in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic Site\;no changes in Kcat Km for esters
| Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
| Ref : Molecular Pharmacology , 50 :1423 , 1996 |
| Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedID: 8967962 |
| Gene_locus related to this paper: human-BCHE |