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Mutation Report for: W231S_human-BCHE

W231S_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Natural mutant
Amino Acid change|W231S
Torpedo number|233
Summary|
Comment|p.W231S Trp231Ser (W259S Trp259Ser in primary sequence with 28 amino-acids signal peptide) Succinylcholine hydrolysis; neuromuscular block duration in excess of 10min. This position had been tested previously by site directed mutation (W231A_human-BCHE) by Masson et al.
Kinetic parameters|none


References:
    Title: Predictors of the variability in neuromuscular block duration following succinylcholine: A prospective, observational study
    Dell-Kuster S, Levano S, Burkhart CS, Lelais F, Zemp A, Schobinger E, Hampl K, Kindler C, Girard T
    Ref: European Journal of Anaesthesiology, :, 2015 : PubMed

            




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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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