Gene Locus : mouse-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site Omega loop conformation test incorporation of the fluorophore acrylodan Boyd_2000_J.Biol.Chem_275_22401 Shi_2001_J.Biol.Chem_276_42196
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Omega loop || Peripheral Anionic Site
Torpedo_number : 121
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Y124C Tyr124Cys Peripheral Anionic Site\;Omega loop conformation test incorporation of the fluorophore acrylodan
| Title : Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop - Shi_2003_J.Biol.Chem_278_30905 |
| Author(s) : Shi J , Tai K , McCammon JA , Taylor P , Johnson DA |
| Ref : Journal of Biological Chemistry , 278 :30905 , 2003 |
| Abstract : Shi_2003_J.Biol.Chem_278_30905 |
| ESTHER : Shi_2003_J.Biol.Chem_278_30905 |
| PubMedSearch : Shi_2003_J.Biol.Chem_278_30905 |
| PubMedID: 12759360 |
| Title : Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites - Johnson_2003_J.Biol.Chem_278_38948 |
| Author(s) : Johnson JL , Cusack B , Hughes TF , McCullough EH , Fauq A , Romanovskis P , Spatola AF , Rosenberry TL |
| Ref : Journal of Biological Chemistry , 278 :38948 , 2003 |
| Abstract : Johnson_2003_J.Biol.Chem_278_38948 |
| ESTHER : Johnson_2003_J.Biol.Chem_278_38948 |
| PubMedSearch : Johnson_2003_J.Biol.Chem_278_38948 |
| PubMedID: 12851386 |
| Title : Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys 69- Cys 96, of mouse acetylcholinesterase - Shi_2002_J.Biol.Chem_277_43301 |
| Author(s) : Shi J , Radic Z , Taylor P |
| Ref : Journal of Biological Chemistry , 277 :43301 , 2002 |
| Abstract : Shi_2002_J.Biol.Chem_277_43301 |
| ESTHER : Shi_2002_J.Biol.Chem_277_43301 |
| PubMedSearch : Shi_2002_J.Biol.Chem_277_43301 |
| PubMedID: 12196517 |
| Title : Reversibly bound and covalently attached ligands induce conformational changes in the Omega loop, Cys 69-Cys 96, of mouse acetylcholinesterase - Shi_2001_J.Biol.Chem_276_42196 |
| Author(s) : Shi J , Boyd AE , Radic Z , Taylor P |
| Ref : Journal of Biological Chemistry , 276 :42196 , 2001 |
| Abstract : Shi_2001_J.Biol.Chem_276_42196 |
| ESTHER : Shi_2001_J.Biol.Chem_276_42196 |
| PubMedSearch : Shi_2001_J.Biol.Chem_276_42196 |
| PubMedID: 11517229 |
| Title : Probing the active center Gorge of acetylcholinesterase by fluorophores Linked to substituted cysteines - Boyd_2000_J.Biol.Chem_275_22401 |
| Author(s) : Boyd AE , Marnett AB , Wong L , Taylor P |
| Ref : Journal of Biological Chemistry , 275 :22401 , 2000 |
| Abstract : Boyd_2000_J.Biol.Chem_275_22401 |
| ESTHER : Boyd_2000_J.Biol.Chem_275_22401 |
| PubMedSearch : Boyd_2000_J.Biol.Chem_275_22401 |
| PubMedID: 10779503 |