Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : oxime interaction reactivation of tabun-inhibited human AChE. Unable to facilitate HI-6-mediated reactivation of tabun-hAChE. Induced a 2-2.5-fold enhancement of the bimolecular rate constant for K027 and HLo-7 Artursson_2009_Toxicology_265_108
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Oxime interaction
Torpedo_number : 121
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Y124F Tyr124Phe (p.Y155F Tyr155Phe in primary sequence with 31 amino-acids signal peptide) oxime interaction\;reactivation of tabun-inhibited human AChE. Unable to facilitate HI-6-mediated reactivation of tabun-hAChE. Induced a 2-2.5-fold enhancement of the bimolecular rate constant for K027 and HLo-7
| Title : Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis - Artursson_2009_Toxicology_265_108 |
| Author(s) : Artursson E , Akfur C , Hornberg A , Worek F , Ekstrom F |
| Ref : Toxicology , 265 :108 , 2009 |
| Abstract : Artursson_2009_Toxicology_265_108 |
| ESTHER : Artursson_2009_Toxicology_265_108 |
| PubMedSearch : Artursson_2009_Toxicology_265_108 |
| PubMedID: 19761810 |